Document Detail

Immediate and short-term effects of pulmonary artery banding on left ventricular performance in foetal sheep.
MedLine Citation:
PMID:  15188984     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate foetal left ventricular performance when its preload was increased by banding the pulmonary artery, a study design where a simultaneous change in left ventricular afterload is unlikely. METHODS: Nine ovine foetuses were studied with real-time images and Doppler echocardiography before, 3-4 and 6-8 d after surgery. Seven of these foetuses were also studied during the surgical intervention, immediately before and within 2 min after banding. RESULTS: The immediate effects of a 90-95% reduction of the pulmonary artery cross-sectional area were: a 53 +/- 20% (mean +/- SD) decrease and a 38 +/- 10% increase of right (RvQ) and left ventricular output (LvQ), respectively. Comparing measurements before and 3-4 d after operation, there was a 64 +/- 16% decrease of RvQ and a 64 +/- 25% increase of LvQ. The increase in LvQ was due to an increase in both heart rate (19 +/- 10%) and stroke volume (38 +/- 18%). After an additional 3-4 postoperative days, heart rate remained increased to the same extent, but there was a more pronounced increase of LvQ (93 +/- 19%) and stroke volume (59 +/- 22%). CONCLUSION: The parallel foetal circulation has a capacity to handle a severely increased afterload for the right ventricle by immediately improving and maintaining an increased left ventricular performance. This improvement was in part accomplished by an increase in stroke volume.
S E Sonesson; J C Fouron; G Teyssier; A Skoll; C Chartrand
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  93     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-06-10     Completed Date:  2004-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  540-4     Citation Subset:  IM    
Foetal Cardiology Unit, Paediatric Cardiology Service, Department of Paediatrics, St. Justine Hospital. University of Montreal, Montreal, Quebec, Canada.
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MeSH Terms
Analysis of Variance
Echocardiography, Doppler
Fetal Heart / physiology*,  ultrasonography
Heart Rate / physiology
Postoperative Period
Pulmonary Artery / surgery*,  ultrasonography
Stroke Volume / physiology
Time Factors
Vascular Surgical Procedures / methods*
Ventricular Function, Left / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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