| Immediate and short-term consequences of secondhand smoke exposure on the respiratory system. | |
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MedLine Citation:
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PMID: 21178628 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This review critically evaluates the existing biological evidence regarding the immediate and short-term respiratory consequences of secondhand smoke (SHS). RECENT FINDINGS: A 1-h exposure to SHS at bar/restaurant levels generates a marked inflammatory reaction and significant decrements on lung function. These deleterious effects of SHS are exacerbated when physical activity follows the SHS exposure, particularly in less fit individuals. The main respiratory effect mechanisms of SHS include a direct induction of growth factors resulting in airway remodelling and alterations in nitric oxide regulation. Pharmacological agents that increase either apical membrane chloride conductance or basolateral membrane potassium conductance may be of therapeutic benefit in patients with diseases related to SHS exposure. Moreover, treatment with statins has shown beneficial effects towards preventing the SHS-induced pulmonary hypertension, vascular remodelling, and endothelial dysfunction. SUMMARY: Based on recently discovered evidence, even brief and short-term exposures to SHS generate significant adverse effects on the human respiratory system. Future research directions in this area include the concentrations of tobacco smoke constituents in the alveolar milieu following SHS exposure, individual susceptibility to SHS, as well as pharmacological treatments for reversing the SHS-induced airway remodelling. |
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Authors:
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Andreas D Flouris; Yiannis Koutedakis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in pulmonary medicine Volume: 17 ISSN: 1531-6971 ISO Abbreviation: Curr Opin Pulm Med Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503765 Medline TA: Curr Opin Pulm Med Country: United States |
Other Details:
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Languages: eng Pagination: 110-5 Citation Subset: IM |
Affiliation:
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aFAME Laboratory, Institute of Human Performance and Rehabilitation, Centre for Research and Technology Thessaly, Trikala, Greece bDepartment of Exercise Sciences, University of Thessaly, Trikala, Greece and School of Sport, Performing Arts and Leisure, University of Wolverhampton, Walsall, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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