Document Detail

Immediate procedural and long-term clinical outcomes following drug-eluting stent implantation to ostial saphenous vein graft lesions.
MedLine Citation:
PMID:  18568570     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ostial saphenous vein graft (OSVG) lesions were excluded from all the clinical trials demonstrating significantly lower restenosis rates with drug-eluting stents (DES) compared to bare metal stents (BMS). This study aimed to evaluate the efficacy of DES in OSVG lesions by assessing angiographic and 12-month clinical outcomes. METHODS: 70 consecutive patients (70 OSVG lesions) underwent coronary stent implantation between May 2003 and April 2006: 37 lesions received DES and 33 lesions BMS. Endpoints were all cause and cardiovascular mortality, myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR), examined separately and as a combined end-point (major adverse cardiac events, MACE). RESULTS: Procedural (94.6% for DES and 87.9% for BMS) and angiographic (100% for DES and 100% for BMS) success did not differ between the two groups. The only in-hospital events were non-Q wave MI (DES 8.1% versus BMS 12.1%, P=0.69). At 30-day follow-up, there were no other events. Overall, at 1-year follow-up, the BMS group had a higher TLR (30.3% versus 5.4%, P=0.015), TVR (33.3% versus 10.8%, P=0.045) and MACE rate (36.4% versus 10.8%, P=0.024) compared to the DES group. CONCLUSIONS: Drug-eluting stent implantation to OSVG lesions achieves better clinical results than BMS but is still associated with a relatively high incidence (10.8%) of revascularization at 1-year follow-up.
Sahin Kaplan; Peter Barlis; Abdulkadir Kiris; Konstantinos Dimopoulos; Sukru Celik; Carlo Di Mario
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acute cardiac care     Volume:  10     ISSN:  1748-2941     ISO Abbreviation:  Acute Card Care     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-11-04     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101276603     Medline TA:  Acute Card Care     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  88-92     Citation Subset:  IM    
Royal Brompton Hospital, Department of Cardiology, London, UK.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary / methods*
Blood Vessel Prosthesis Implantation / instrumentation*
Coated Materials, Biocompatible*
Coronary Angiography
Coronary Disease / mortality,  radiography,  surgery*
Follow-Up Studies
Retrospective Studies
Saphenous Vein / transplantation*
Survival Rate / trends
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Coated Materials, Biocompatible

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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