Document Detail

Immediate post-operative MRI suggestive of the site and timing of glioblastoma recurrence after gross total resection: a retrospective longitudinal preliminary study.
MedLine Citation:
PMID:  23314599     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To retrospectively identify morphological and physiological post-operative magnetic resonance imaging (MRI) characteristics predictive of glioblastoma recurrences after gross total resection (gross-TR).
METHODS: Resection margins of 24 glioblastoma were analysed immediately post-operatively (MRI ≤ 2 h) and early post-operatively (24 h ≤ MRI ≤ 48 h), and subdivided into areas with and without subtle contrast enhancement previously considered non-specific. On follow-up MRI, tumour regrowth areas were subdivided according to recurrence extent (focally/extended) and delay (≤6 and ≥12 months). Co-registration of pre-operative, immediately post-operative and early post-operative MRI with the first follow-up MRI demonstrating recurrence authorised their morphological (contrast enhancements) and physiological (rCBV) characterisation.
RESULTS: Morphologically, on immediately post-operative MRI, micro-nodular and frayed enhancements correlate significantly with early recurrences (≤6 months). After gross-TR the absence of these enhancements is associated with a significant increase in progression-free survival (61 vs 15 weeks respectively) and overall survival (125 vs 51 weeks respectively). Physiologically, areas with a future focal recurrence have a trend toward higher rCBV than other areas.
CONCLUSION: Immediately post-operative topography of micro-nodular and frayed enhancements is suggestive of recurrence location and delay. Absence of such enhancements is associated with a fourfold increase in progression-free survival and a 2.5-fold increase in overall survival.
KEY POINTS: • Immediately post-operative MRI reveals contrast enhancement after glioblastoma gross total resection. • Immediately post-operative micro-nodular and frayed enhancement correlate with early recurrence. • Absence of micro-nodular/frayed enhancement is associated with 61 weeks' progression-free survival. • Absence of micro-nodular/frayed enhancement is associated with 125 weeks' overall survival.
Thibault Smets; Tévi Morel Lawson; Cécile Grandin; Aleksandar Jankovski; Christian Raftopoulos
Related Documents :
6647839 - Pleural calcification with persistent effusion.
10524869 - Xenon versus ceramics: a comparison of two ct x-ray detector systems.
24699349 - Iterative ct reconstruction via minimizing adaptively reweighted total variation.
24831379 - Mature cystic teratoma of skull base and attached to the wall of third ventricle.
11452059 - Radiographic and ct appearances of the major fissures.
644179 - Computed tomography of the thorax.
1780109 - Gated 99tcm-mibi myocardial function imaging.
20173149 - Acetabular labral tears and cartilage lesions of the hip: indirect mr arthrographic cor...
25247969 - Lymphoid nodular hyperplasia of the terminal ileum can mimic active crohn disease on mr...
Publication Detail:
Type:  Journal Article     Date:  2013-01-12
Journal Detail:
Title:  European radiology     Volume:  23     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-17     Completed Date:  2013-12-26     Revised Date:  2014-08-26    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1467-77     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Brain Neoplasms / diagnosis,  pathology*,  surgery
Contrast Media / pharmacology
Disease-Free Survival
Glioblastoma / diagnosis,  pathology*,  surgery
Longitudinal Studies
Magnetic Resonance Imaging / methods*
Middle Aged
Neoplasm Recurrence, Local
Postoperative Period
Retrospective Studies
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Real-time X-ray-based 4D image guidance of minimally invasive interventions.
Next Document:  Iterative reconstruction techniques for computed tomography Part 1: Technical principles.