Document Detail

Immediate oxygen therapy prevents brain cell injury in carbon monoxide poisoned rats without loss of consciousness.
MedLine Citation:
PMID:  16814444     Owner:  NLM     Status:  MEDLINE    
In CO-poisoned patients without loss of consciousness no significant long-term functional differences in outcome have been shown in any hyperbaric versus normobaric oxygen studies. Since brain histology changes cannot be studied in CO-poisoned patients we evaluated the efficacy of normobaric and hyperbaric oxygen therapy in preventing brain cell injury in CO-poisoned animals without loss of consciousness. Wistar rats without loss of consciousness after exposure to 3000ppm of CO for 60min were exposed to ambient air (group 1), 100% oxygen at a pressure of 1bar (group 2) and 100% oxygen at a pressure of 3bar (group 3). The rats were sacrificed after two weeks, brain samples were stained with hematoxylin-eosin and a percentage of pyknotic cells in hippocampus was reported. Analyses of differences in percentage of pyknotic cells between different kinds of therapy showed that the percentage of pyknotic cells of the second group (2.3+/-1.2%) treated with normobaric oxygen and the third group (4.5+/-4.0%) treated with hyperbaric oxygen were similar, and both of them were significantly different, with a much lower percentage of pyknotic cells, from the first group left on ambient air (47.7+/-10.0%). In conclusion, immediate normobaric and hyperbaric oxygen therapy equally prevents hippocampal cell injury in CO-poisoned rats without loss of consciousness.
Matjaz Bunc; Bostjan Luzar; Zarko Finderle; Dusan Suput; Miran Brvar
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Publication Detail:
Type:  Journal Article     Date:  2006-05-26
Journal Detail:
Title:  Toxicology     Volume:  225     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  138-41     Citation Subset:  IM    
Institute of Pathophysiology, School of Medicine, University of Ljubljana, Zaloska cesta 4, Slovenia.
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MeSH Terms
Brain Diseases / pathology,  prevention & control*,  therapy
Carbon Monoxide Poisoning / pathology,  therapy*
Cell Death
Cell Nucleus / drug effects,  pathology
Disease Models, Animal
Hippocampus / drug effects,  pathology
Hyperbaric Oxygenation / methods*
Neurons / drug effects,  pathology
Rats, Wistar

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