Document Detail

Immediate nonallergic psychotic reaction to intramuscular procaine penicillin.
MedLine Citation:
PMID:  7591460     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Though little known by medical personnel, an immediate nonallergic psychotic reaction to intramuscular procaine penicillin has been reported occasionally from many countries since 1951. MATERIALS AND METHODS: A case report describes a patient whose violent behavior, provoked by this reaction, resulted in legal action taken against him. Two other nonviolent cases are presented and are followed by a review of the literature. RESULTS: Signs and symptoms of this reaction that appears to be to the procaine component resemble a pressor response and are therefore contrary to the signs and symptoms of an anaphylactic reaction. Anxiety, hallucinations, hypertension, and tachycardia are characteristic. The reaction is self-limited. Long-term psychologic sequelae might be averted by adequate reassurance. CONCLUSIONS: The importance of procaine penicillin as an essential drug in many parts of the world should not be diminished; however, recognition of acute nonallergic psychotic reactions is of paramount importance to assure proper patient management and to avoid misinterpretation of aggressive behavior.
E M Einterz; R M Einterz
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  34     ISSN:  0011-9059     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-12-21     Completed Date:  1995-12-21     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  627-9     Citation Subset:  IM    
H?pital d'Arrondissement, Kolofata, Cameroun.
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MeSH Terms
Injections, Intramuscular
Penicillin G Procaine / administration & dosage,  adverse effects*
Psychoses, Substance-Induced / etiology*
Reg. No./Substance:
6130-64-9/Penicillin G Procaine

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