Document Detail

Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis.
MedLine Citation:
PMID:  21163545     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Early neuroendocrine pathways contribute to liver regeneration after partial hepatectomy (PH). We investigated one of these pathways involving acute cholestasis, immediate portal hyperpressure, and arginine vasopressin (AVP) secretion.
METHODS: Surgical procedure (PH, Portal vein stenosis (PVS), bile duct ligation (BDL), spinal cord lesion (SCL)) and treatments (capsaicin, bile acids (BA), oleanolic acid (OA)) were performed on rats and/or wild type or TGR5 (GPBAR1) knock-out mice. In these models, the activation of AVP-secreting supraoptic nuclei (SON) was analyzed, as well as plasma BA, AVP, and portal vein pressure (PVP). Plasma BA, AVP, and PVP were also determined in human living donors for liver transplantation.
RESULTS: Acute cholestasis (mimicked by BDL or BA injection) as well as portal hyperpressure (mimicked by PVS) independently activated SON and AVP secretion. BA accumulated in the brain after PH or BDL, and TGR5 was expressed in SON. SON activation was mimicked by the TGR5 agonist OA and inhibited in TGR5 KO mice after BDL. An afferent nerve pathway also contributed to post-PH AVP secretion, as capsaicin treatment or SCL resulted in a weaker SON activation after PH.
CONCLUSIONS: After PH in rodents, acute cholestasis and portal hypertension, via the nervous and endocrine routes, stimulate the secretion of AVP that may protect the liver against shear stress and bile acids overload. Data in living donors suggest that this pathway may also operate in humans.
Isabelle Doignon; Boris Julien; Valérie Serrière-Lanneau; Isabelle Garcin; Gérard Alonso; Alexandra Nicou; François Monnet; Michelle Gigou; Lydie Humbert; Dominique Rainteau; Daniel Azoulay; Denis Castaing; Marie-Christine Gillon; Didier Samuel; Jean-Charles Duclos-Vallée; Thierry Tordjmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-22
Journal Detail:
Title:  Journal of hepatology     Volume:  54     ISSN:  1600-0641     ISO Abbreviation:  J. Hepatol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-18     Completed Date:  2011-06-21     Revised Date:  2012-08-24    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  481-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
INSERM U.757, Université Paris Sud, bât. 443, 91405 Orsay, France.
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MeSH Terms
Arginine Vasopressin / physiology
Bile Acids and Salts / physiology
Blood Pressure / physiology
Cholestasis / physiopathology
Hypertension, Portal / physiopathology
Liver Regeneration / physiology*
Mice, Inbred C57BL
Mice, Knockout
Models, Animal
Neurosecretory Systems / physiology*
Portal System / physiology
Rats, Wistar
Receptors, G-Protein-Coupled / deficiency,  genetics,  physiology
Signal Transduction
Supraoptic Nucleus / physiology
Reg. No./Substance:
0/Bile Acids and Salts; 0/Gpbar1 protein, mouse; 0/Receptors, G-Protein-Coupled; 113-79-1/Arginine Vasopressin
Comment In:
J Hepatol. 2011 Mar;54(3):403-5   [PMID:  21084132 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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