| Immediate and long-term effects of color Doppler ultrasound on myocardial cell apoptosis of fetal rats. | |
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MedLine Citation:
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PMID: 15901293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this article is to evaluate the safety of diagnostic color Doppler ultrasound (CDUS) on embryos by observing its effects on myocardial cell apoptosis of fetal rats. Pregnant Sprague-Dawley rats were divided into fetal group and neonatal group according to the sample-drawing time averagely and randomly, and each group was subdivided into control group and insonification group. The control group was sham-insonificated, and the insonification group was insonificated by diagnostic ultrasound (3.0 MHz, Tis = 1.8, MI = 1.6) for 30 minutes. The fetal rats' hearts were removed 24 hours after insonification and the neonatal rats' hearts were removed 10 days after birth. Apoptosis cells were detected with TUNEL (in situ terminal deoxynucleotidyl transferase-mediated D-UTP nick end labeling), and ultrastructural changes were observed with transmission electron microscope. Myocardial cell apoptosis was significantly higher in the fetal insonification group than in the fetal control group (P < 0.05), and it was significantly higher in the fetal groups than in the neonatal groups (P < 0.05), but there was no significant difference in myocardial cell apoptosis between the neonatal groups (P < 0.05). Apoptotic changes of myocardial cells in the fetal insonification group were observed with transmission electron microscope, which showed margination, condensation of the nuclear chromatin, etc. It is concluded that apoptosis and ultrastructural changes could be induced if fetal rat's heart was irradiated continuously over 30 minutes by diagnostic CDUS, but this phenomenon would disappear after birth. |
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Authors:
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Huaping Jia; Yunyou Duan; Tiesheng Cao; Baishan Zhao; Faqin Lv; Lijun Yuan |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 22 ISSN: 0742-2822 ISO Abbreviation: Echocardiography Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-19 Completed Date: 2005-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
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Languages: eng Pagination: 415-20 Citation Subset: IM |
Affiliation:
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Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. jiahuaping@yahoo.com.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / radiation effects* Echocardiography, Doppler, Color* Female Fetal Heart / embryology, ultrasonography*, ultrastructure Follow-Up Studies In Situ Nick-End Labeling Male Microscopy, Confocal Microscopy, Electron, Transmission Myocardium / ultrastructure* Pregnancy Random Allocation Rats Rats, Sprague-Dawley Safety Time Factors Ultrasonics* Ultrasonography, Prenatal / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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