| Immediate hypothermia reduces cardiac troponin I after hypoxic-ischemic encephalopathy in newborn pigs. | |
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MedLine Citation:
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PMID: 21691250 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal hypoxic-ischemic encephalopathy (HIE) is a clinically defined neurological condition after lack of oxygen and often associated with cardiac dysfunction in term infants. Therapeutic hypothermia (HT) after birth is neuroprotective in infants with HIE. However, it is not known whether HT is also cardioprotective. Four newborn pigs were used in the pilot study and a further 18 newborn pigs [randomly assigned to 72 h normothermia (NT) or 24 h HT followed by 48 h NT] were subjected to global HIE insults. Serum cTnI was measured before and post the HIE insult. Blood pressure, inotropic support, blood gases, and heart rate (HR) were recorded throughout. Cardiac pathology was assessed from histological sections. Cooling reduced serum cTnI levels significantly in HT pigs by 6 h (NT, 1.36 ± 0.67; HT, 0.34 ± 0.23 ng/mL; p = 0.0009). After rewarming, from 24 to 30 h postinsult, HR and cTnI increased in the HT group; from HR[24 h] = 117 ± 22 to HR[30 h] = 218 ± 32 beats/min (p = 0.0002) and from cTnI[24 h] = 0.23 ± 0.12 to cTnI[30 h] = 0.65 ± 0.53 ng/mL, (p = 0.05). There were fewer ischemic lesions on cardiac examination (37%) in the HT group compared with the NT group (70%). HT (24 h) pigs did not have the postinsult cTnI increase seen in NT-treated pigs. There was a trend that HT improved cardiac pathology in this 3-d survival model. |
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Authors:
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Xun Liu; James Tooley; Else M Løberg; M Saadeh Suleiman; Marianne Thoresen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 70 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-02 Completed Date: 2011-12-19 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 352-6 Citation Subset: IM |
Affiliation:
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Child Health, School of Clinical Sciences, University of Bristol, Bristol BS2 8EG, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Blood Pressure / physiology Body Temperature / physiology Humans Hypothermia, Induced* Hypoxia-Ischemia, Brain / physiopathology*, therapy* Myocardium / metabolism*, pathology Pilot Projects Random Allocation Swine Troponin I / blood* |
| Grant Support | |
ID/Acronym/Agency:
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059061//Wellcome Trust; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Troponin I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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