Document Detail


Immediate hypothermia reduces cardiac troponin I after hypoxic-ischemic encephalopathy in newborn pigs.
MedLine Citation:
PMID:  21691250     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal hypoxic-ischemic encephalopathy (HIE) is a clinically defined neurological condition after lack of oxygen and often associated with cardiac dysfunction in term infants. Therapeutic hypothermia (HT) after birth is neuroprotective in infants with HIE. However, it is not known whether HT is also cardioprotective. Four newborn pigs were used in the pilot study and a further 18 newborn pigs [randomly assigned to 72 h normothermia (NT) or 24 h HT followed by 48 h NT] were subjected to global HIE insults. Serum cTnI was measured before and post the HIE insult. Blood pressure, inotropic support, blood gases, and heart rate (HR) were recorded throughout. Cardiac pathology was assessed from histological sections. Cooling reduced serum cTnI levels significantly in HT pigs by 6 h (NT, 1.36 ± 0.67; HT, 0.34 ± 0.23 ng/mL; p = 0.0009). After rewarming, from 24 to 30 h postinsult, HR and cTnI increased in the HT group; from HR[24 h] = 117 ± 22 to HR[30 h] = 218 ± 32 beats/min (p = 0.0002) and from cTnI[24 h] = 0.23 ± 0.12 to cTnI[30 h] = 0.65 ± 0.53 ng/mL, (p = 0.05). There were fewer ischemic lesions on cardiac examination (37%) in the HT group compared with the NT group (70%). HT (24 h) pigs did not have the postinsult cTnI increase seen in NT-treated pigs. There was a trend that HT improved cardiac pathology in this 3-d survival model.
Authors:
Xun Liu; James Tooley; Else M Løberg; M Saadeh Suleiman; Marianne Thoresen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  70     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2011-12-19     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-6     Citation Subset:  IM    
Affiliation:
Child Health, School of Clinical Sciences, University of Bristol, Bristol BS2 8EG, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Blood Pressure / physiology
Body Temperature / physiology
Humans
Hypothermia, Induced*
Hypoxia-Ischemia, Brain / physiopathology*,  therapy*
Myocardium / metabolism*,  pathology
Pilot Projects
Random Allocation
Swine
Troponin I / blood*
Grant Support
ID/Acronym/Agency:
059061//Wellcome Trust; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Troponin I
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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