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Immediate hypersensitivity and serum IgE antibody responses in patients with dermatophytosis.
MedLine Citation:
PMID:  22523906     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: The association of dermatophytes with atopic patients and improvement in allergic signs with antifungal treatment suggest a possible link between chronic infection and atopy.
OBJECTIVE: The purpose of this study was to determine skin reactivity and serum IgE antibody responses in patients with chronic and acute dermatophytosis.
METHODS: One hundred and sixty-three patients with chronic dermatophytosis, 35 patients with acute dermatophytosis, 41 atopic patients and 49 healthy subjects were enrolled in this study. Sensitization to Trichophyton mentagrophytes (T. mentagrophytes), Candida albicans and Aspergillus fumigatus antigens has been evaluated in patients by skin prick test (SPT) and by the presence of specific IgE antibody in enzyme-linked immuno-sorbent assay (ELISA).
RESULTS: Positive immediate hypersensitivity (IH) reactions were obtained in 95.1% of the atopic patients with chronic infection for T. mentagrophytes, representing a significant difference from other patient groups (P < 0.05). Specificanti-T. mentagrophytes IgE antibodies were detected in atopic patients with chronic (65.9%) and acute (50%) dermatophytosis, while none of the atopic subjects had positive IgE reactions to T. mentagrophytes.
CONCLUSION: The results showed significant higher positive IH and specific anti-T. mentagrophytes IgE responses in atopic patients with chronic dermatophytosis than the other groups.
Authors:
Ali Reza Khosravi; Hojjatollah Shokri; Parvin Mansouri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand     Volume:  30     ISSN:  0125-877X     ISO Abbreviation:  Asian Pac. J. Allergy Immunol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402034     Medline TA:  Asian Pac J Allergy Immunol     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  40-7     Citation Subset:  IM    
Affiliation:
Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Khosravi@ut.ac.ir
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