| Immediate hemodynamic effects of thrombolytic therapy on the ischemic myocardium. | |
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MedLine Citation:
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PMID: 8804773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombolytic agents are used to restore coronary artery perfusion and limit the size of a myocardial infarction. The systemic effects of these drugs, streptokinase (SK), urokinase (UK), and recombinant tissue plasminogen activator (rtPA), have been studied extensively. Although their effects on rheology and late myocardial performance have been well-documented to date, there have not been any studies evaluating the acute hemodynamic consequences of thrombolytics immediately after administration. In this report we use an isolated Langendorf rodent heart preparation to evaluate the acute hemodynamic effects of thrombolytic therapy on both the normal and the ischemic myocardium. We quantified performance by documenting cardiac output, coronary blood flow, and blood pressure. Although each thrombolytic agent significantly transiently impairs cardiac performance, differences in effect between the agents were statistically insignificant. This was also the case with both the normal as well as the ischemic myocardium. The results of this study would not support favoring the use of one of these agents over the other with regards to primary myocardial performance. |
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Authors:
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R L Quigley; M J Khandekar; S S Switzer; M H Salinger |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular diagnosis Volume: 38 ISSN: 0098-6569 ISO Abbreviation: Cathet Cardiovasc Diagn Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-12-16 Completed Date: 1996-12-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7508512 Medline TA: Cathet Cardiovasc Diagn Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 325-30 Citation Subset: IM |
Affiliation:
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Department of Surgery, Guthrie Clinic, Sayre, Pennsylvania 18840, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hemodynamics* / drug effects Male Myocardial Ischemia / drug therapy*, physiopathology* Rats Rats, Inbred Lew Recombinant Proteins Reference Values Streptokinase / therapeutic use Thrombolytic Therapy* Tissue Plasminogen Activator / therapeutic use Urokinase-Type Plasminogen Activator / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; EC 3.4.-/Streptokinase; EC 3.4.21.68/Tissue Plasminogen Activator; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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