Document Detail


Immediate force loss after eccentric contractions is increased with L-NAME administration, a nitric oxide synthase inhibitor.
MedLine Citation:
PMID:  23349083     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Nitric oxide (NO) signaling regulates many biological processes in skeletal muscle, wherein aberrant signaling contributes to myopathic conditions (e.g., Duchenne muscular dystrophy). NO has been shown to play a role in muscle regeneration after injury. However, less is known about its role during injury. In this study we aimed to determine whether NO synthase (NOS) inhibition exacerbates functional deficits immediately after the performance of eccentric contractions.
METHODS: Wild-type mouse extensor digitorum longus (EDL) muscles underwent in vitro functional testing in the presence or absence of a non-specific NOS inhibitor (L-NAME, 10 mM) before and after performance of 10 eccentric contractions.
RESULTS: After eccentric contractions, P(o) was reduced by ∽25% for muscle in regular physiological solution but by ∽50% with the addition of L-NAME (P = 0.009).
CONCLUSIONS: Non-specific blockade of NOS exacerbates functional deficits immediately after eccentric contractions, suggesting that NO signaling protects skeletal muscle from excessive injury in healthy muscle.
Authors:
Benjamin T Corona; Christopher P Ingalls
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Muscle & nerve     Volume:  47     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-03-21     Revised Date:  2013-12-17    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Enzyme Inhibitors / pharmacology*
Male
Mice
Muscle Contraction / drug effects*,  physiology
Muscle, Skeletal / drug effects*,  physiology
NG-Nitroarginine Methyl Ester / pharmacology*
Nitric Oxide Synthase / antagonists & inhibitors*
Grant Support
ID/Acronym/Agency:
AR-41802/AR/NIAMS NIH HHS; R01 AR041802/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; EC 1.14.13.39/Nitric Oxide Synthase; V55S2QJN2X/NG-Nitroarginine Methyl Ester
Comments/Corrections

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