| Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome. | |
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MedLine Citation:
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PMID: 20445953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Marfan syndrome (MS) is a dominant autosomal disease caused by mutations in chromosome 15, the locus controlling fibrillin 1 synthesis, and may exhibit skeletal, ocular, cardiovascular, and other manifestations. Pulse wave velocity (PWV) is used to measure arterial elasticity and stiffness and is related to the elastic properties of the vascular wall. Since the practice of exercise is limited in MS patients, it was of interest to analyze the acute effect of submaximal exercise on aortic distensibility using PWV and other hemodynamic variables in patients with MS with either mild or no aortic dilatation. PWV and physiological variables were evaluated before and after submaximal exercise in 33 patients with MS and 18 controls. PWV was 8.51 + or - 0.58 at rest and 9.10 + or - 0.63 m/s at the end of exercise (P = 0.002) in the group with MS and 8.07 + or - 0.35 and 8.98 + or - 0.56 m/s in the control group, respectively (P = 0.004). Comparative group analysis regarding PWV at rest and at the end of exercise revealed no statistically significant differences. The same was true for the group that used beta-blockers and the one that did not. The final heart rate was 10% higher in the control group than in the MS group (P = 0.01). Final systolic arterial pressure was higher in the control group (P = 0.02). PWV in MS patients with mild or no aortic dilatation did not differ from the control group after submaximal effort. |
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Authors:
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P Peres; G F Bernardelli; C C Mendes; S S C P M Fischer; D M Servantes; W M Medeiros; A C Carvalho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-19 |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 43 ISSN: 1414-431X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-06 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: Brazil |
Other Details:
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Languages: eng Pagination: 397-402 Citation Subset: IM |
Affiliation:
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Disciplina de Cardiologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil. pp.peres@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aorta
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physiology* Blood Flow Velocity / physiology Blood Pressure / physiology Case-Control Studies Cross-Sectional Studies Exercise Test* Exercise Tolerance / physiology* Female Humans Male Marfan Syndrome / physiopathology* Pulsatile Flow / physiology Vasodilation / physiology* Young Adult |
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