Document Detail


Immediate effects of intravenous cocaine on the thoracic aorta and coronary arteries. A transesophageal echocardiographic study.
MedLine Citation:
PMID:  8681619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MEASUREMENTS AND RESULTS: Immediately after cocaine infusion, average heart rate, systolic BP, and double product were increased compared with baseline (22%, 15%, 35%, respectively). There was no significant change in the diameters of the ascending aorta (27.5 vs 27.1 mm; p = 0.85), the descending aorta (19.8 vs 20.4 mm; p = 0.62), or the left main coronary artery (4.3 vs 4.7 mm; p = 0.15). However, there was a trend for an increase in coronary blood flow immediately after cocaine (226 vs 309 mL/min; p = 0.10).
CONCLUSIONS: We conclude that in the 15 subjects studied, there was no evidence of thoracic aorta of coronary artery vasoconstriction immediately after i.v. cocaine. Instead, we found that the diameters of the thoracic aorta and the left main coronary artery were unchanged, and that there was a trend for augmentation of coronary artery blood flow.
Authors:
M J Eisenberg; D L Yakel; J Mendelson; R F Redberg; R T Jones; E Foster
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  110     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-21     Completed Date:  1996-08-21     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, John Henry Mills Echocardiography Laboratory, University of California, San Francisco 94143-0984, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aorta, Thoracic / drug effects*,  physiology,  ultrasonography
Arteries / drug effects
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Cocaine / administration & dosage,  pharmacology*
Coronary Circulation / drug effects
Coronary Vessels / drug effects*,  physiology,  ultrasonography
Echocardiography, Transesophageal*
Female
Heart Rate / drug effects
Humans
Injections, Intravenous
Male
Middle Aged
Vasoconstriction / drug effects
Grant Support
ID/Acronym/Agency:
DA00053/DA/NIDA NIH HHS; DA010696/DA/NIDA NIH HHS; DA02829/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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