| Immediate effect of nephrotoxic serum on kidney function in the dog. | |
| | |
MedLine Citation:
|
PMID: 895967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Nephrotoxic anitbody rapidly fixes to glomerular basement membrane following systemic injection and immediately initiates histopathologic alterations. We studied the functional changes induced by nephrotoxic serum (NTS) in dogs starting 20 min after injection using three different protocols. By this time the GFR, UNa V and FENa had decreased in each study. Volume expansion resulted in a significantly smaller absolute increase in FENa than in the preinjection control study (1.1 vs. 2.8%, p less than 0.005), while maximum tubular secretion of PAH (TmPAH) and reabsorption of glucose (Tm glucose) stayed constant following NTS; thus TmPAH/GFR and Tm glucose/GFR increased significantly. These studies demonstrate that glomerular function is rapidly affected by NTS while absolute tubular function is relatively well maintained. Since histologic and functional changes occurred simultaneously, it seems likely that the functional changes were the direct consequence of the pathologic alterations. |
| | |
Authors:
|
J P Wagnild |
Related Documents
:
|
1283527 - Early changes of urinary amylase isoenzymes in diabetes mellitus. 8137717 - Effects of cilostazol, a phosphodiesterase inhibitor, on urinary excretion of albumin a... 8546507 - Is microalbuminuria progressive? 16295047 - Effect of lercanidipine compared with ramipril on albumin excretion rate in hypertensiv... 9472867 - An intensive weight loss programme in established type 2 diabetes and controls: effects... 10664317 - Impact of the 1997 american diabetes association criteria on classification of glucose ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nephron Volume: 19 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1977 |
Date Detail:
|
Created Date: 1977-10-28 Completed Date: 1977-10-28 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 167-75 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibodies* / administration & dosage Dogs Glomerular Filtration Rate Glucose / metabolism Kidney / metabolism, physiopathology* Kidney Function Tests Kidney Glomerulus / immunology Nephritis / immunology* Sodium / urine |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies; 50-99-7/Glucose; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alleviation of anoxic experimental acute renal failure in rats by beta-adrenergic blockade.
Next Document: Intraspinal dermoids.