Document Detail

Immediate contact reactions to cow's milk and egg in atopic children.
MedLine Citation:
PMID:  1678237     Owner:  NLM     Status:  MEDLINE    
Forty children (0-5 years old), presented with immediate contact urticaria, rash and often atopic dermatitis (n = 34). Redness or urticaria around the mouth appearing after consuming cow's milk or egg, were the major complaints in all. These symptoms suggested a food-induced immediate contact reaction, which can be immune-mediated or irritative. To reinduce this reaction, a skin provocation test, called SAFT, was performed. SAFT stands for Skin Application Food Test. This test is based on direct skin contact, during a maximum of 30 min with food in its 'ordinary consumptive state'. The SAFT can be regarded as a 'physiological' provocation patch test. If positive, contact urticaria develops most often within a few minutes. The results of SAFT and IgE RAST correlated significantly well. Total IgE values were not informative. The rapid onset of the SAFT reaction, induced by proteins, supported by RAST results, strongly indicates an immune-mediated mechanism. In 52% of the 34 patients with atopic dermatitis, dermatitis was exacerbated following food-to-skin contact. Immune-mediated contact reactions to foods play an important role in (dermal) food allergy.
A P Oranje; R S Aarsen; P G Mulder; G Liefaard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  71     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1991  
Date Detail:
Created Date:  1991-09-12     Completed Date:  1991-09-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  263-6     Citation Subset:  IM    
Department of Dermatology and Venereology, Division of Paediatric Dermatology, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Child, Preschool
Dermatitis, Contact / immunology*
Eggs / adverse effects*
Hypersensitivity, Immediate / immunology*
Immunoglobulin E / analysis
Milk Hypersensitivity / immunology*
Mouth / pathology
Radioallergosorbent Test
Reg. No./Substance:
37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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