Document Detail

Immediate contact reactions to chemicals in the fragrance mix and a study of the quenching action of eugenol.
MedLine Citation:
PMID:  2248889     Owner:  NLM     Status:  MEDLINE    
In this study, the nature of non-immune immediate contact reactions (NIICR) produced by cinnamic aldehyde, benzoic acid and sorbic acid were investigated, with particular interest in the 'quenching' ability of eugenol. Three groups of human subjects were studied, and the guinea-pig ear was also used as a model of NIICR. Cinnamic aldehyde, benzoic acid and sorbic acid were all able to produce NIICR in the majority of subjects studied. There was a strong correlation between the susceptibility of each subject to each urticant, but no correlation between the susceptibility to NIICR and age, atopic status or tanning ability. Eugenol caused a reduction in NIICR induced by all three urticants. This 'quenching' effect was apparent even when the eugenol was applied up to 60 min prior to application of cinnamic aldehyde, and its effect was not eliminated by washing. In the guinea-pig-ear model, ear thickening was induced by all three urticants, and this response was inhibited by eugenol.
R J Safford; D A Basketter; C F Allenby; B F Goodwin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  123     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-01-16     Completed Date:  1991-01-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  595-606     Citation Subset:  IM    
Environmental Safety Laboratory, Unilever Research and Engineering, Sharnbrook, Bedford, U.K.
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MeSH Terms
Acrolein / analogs & derivatives,  toxicity
Benzoates / toxicity
Benzoic Acid
Child, Preschool
Dermatitis, Contact / etiology*
Eugenol / therapeutic use*
Guinea Pigs
Hypersensitivity, Delayed
Hypersensitivity, Immediate
Immunoglobulin E
Middle Aged
Perfume / toxicity*
Sorbic Acid / toxicity
Time Factors
Urticaria / chemically induced*,  prevention & control
Reg. No./Substance:
0/Benzoates; 0/Perfume; 104-55-2/cinnamic aldehyde; 107-02-8/Acrolein; 110-44-1/Sorbic Acid; 37341-29-0/Immunoglobulin E; 65-85-0/Benzoic Acid; 97-53-0/Eugenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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