Document Detail

Immature sinus histiocytes. Their identification as a novel B-cell population.
MedLine Citation:
PMID:  6207734     Owner:  NLM     Status:  MEDLINE    
The true nature of cells of "immature sinus histiocytosis" (ISH) is uncertain because they lack the typical features of normal histiocytes when analyzed by enzyme cytochemistry or electron microscopy. In the present study the antigenic profile of ISH cells has been analyzed by immunohistologic techniques in six cases of Piringer's lymphadenitis with the use of a large panel of monoclonal and polyclonal antibodies reactive with the major cell types of the hematolymphoid system. The results obtained indicate that ISH cells consistently lack markers found on cells of the monocyte/macrophage series, myeloid cells, interdigitating reticulum cells, follicular dendritic reticulum cells, T cells, or Ki-1-positive cells. They constantly express B-cell antigens and HLA-DR and (on a variable proportion of cells) surface immunoglobulin. The application of antibodies reactive with different B-cell subsets showed that the cells of ISH do not correspond to any previously described B-cell population, eg, pre-B cells, germinal center cells, follicular mantle lymphocytes, or marginal zone cells. Furthermore, ISH cells and germinal center cells are found in association with clearly different cell types. These findings indicate that ISH cells represent a B-cell population at a previously undescribed differentiation stage, occurring only under certain circumstances (eg, in toxoplasmosis or AIDS). It is proposed that the term "immature sinus histiocytosis" be replaced by "B-cell sinus reaction."
H Stein; K Lennert; D Y Mason; S Liangru; A Ziegler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of pathology     Volume:  117     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-11-05     Completed Date:  1984-11-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  44-52     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Monoclonal / diagnostic use
Antigens / analysis
B-Lymphocytes / classification*
Epitopes / analysis
HLA-DR Antigens
Histiocytes / classification*,  immunology,  ultrastructure
Histocompatibility Antigens Class II / analysis
Immunoenzyme Techniques
Immunoglobulin M / analysis
Lymph Nodes / pathology*
Lymphadenitis / pathology*
Microscopy, Electron
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens; 0/Epitopes; 0/HLA-DR Antigens; 0/Histocompatibility Antigens Class II; 0/Immunoglobulin M

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