Document Detail

Immature parietal cells in healing gastric wounds respond to stimulation. An experimental study in rats.
MedLine Citation:
PMID:  7128950     Owner:  NLM     Status:  MEDLINE    
Ulcers were produced in the gastric mucosa in rats. After 90 days of healing, one group of animals was given pentagastrin and carbacholine via continuous subcutaneous infusion. After 1 h the animals were killed and the wounds and normal mucosa beside the wounds were prepared for electron microscopy. Stereological analyses of regenerating parietal cells from the wounds revealed that stimulation by the secretagogues increased the secretory surface density by some 76%. pH studies were performed in the wounds in another group of animals after the same stimulation as above, and it was found that the secretory product was acid. Thus, immature parietal cells in healing gastric wounds reacted normally to the secretagogues given and they were able to secrete HCl.
H Blom
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestion     Volume:  24     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
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MeSH Terms
Gastric Mucosa / physiopathology
Hydrogen-Ion Concentration
Microscopy, Electron
Rats, Inbred Strains
Stimulation, Chemical
Stomach Ulcer / pathology*,  physiopathology
Wound Healing*

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