Document Detail

Immature oocyte retrieval with in-vitro oocyte maturation.
MedLine Citation:
PMID:  10369206     Owner:  NLM     Status:  MEDLINE    
Early studies of in-vitro fertilization used immature oocytes. The process evolved to retrieving metaphase II oocytes, and was eventually successful. At present, aggressive ovulation induction protocols are the mainstay of assisted reproductive technology programs, but not without increased cost, multiple gestations, morbidity, potential future risks and isolated mortalities. The ability to retrieve each month's cohort of immature oocytes transvaginally opened the door to search for a new option for infertile couples requiring assisted reproductive technology. Immature oocyte retrieval combined with in-vitro oocyte maturation eliminates the stimulation, costs and time that were required to monitor oocytes, along with the short- and long-term complications. The essential components are optimal maturation media and a synchronized endometrium in which the embryos transferred from a truncated follicular phase can implant. The process has been successful in several centers with an acceptable success rate when used in conjunction with a host uterus. Future research with maturation, culture, and endometrial synchronization may allow immature oocyte retrieval with in-vitro oocyte maturation to replace in-vitro fertilization in its present form.
J B Russell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  11     ISSN:  1040-872X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-02     Completed Date:  1999-08-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  289-96     Citation Subset:  IM    
Center for Human Reproduction, Newark, Delaware 19713, USA.
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MeSH Terms
Culture Techniques
Endometrium / physiology
Fertilization in Vitro*
Menstrual Cycle / physiology
Oocytes / cytology,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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