| Immature Citrus sunki Peel Extract Exhibits Antiobesity Effects by β-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice. | |
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MedLine Citation:
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PMID: 22293353 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The peel of Citrus sunki HORT. ex TANAKA has been widely used in traditional Asian medicine for the treatment of many diseases, including indigestion and bronchial asthma. In this study, we investigated the antiobesity activity of immature C. sunki peel extract (designated CSE) using high-fat diet (HFD)-induced obese C57BL/6 mice and mature 3T3-L1 adipocytes. In the animal study, body weight gain, adipose tissue weight, serum total cholesterol, and triglyceride in the CSE-administered group decreased significantly compared to the HFD group. Also, CSE supplementation reduced serum levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, and lactate dehydrogenase. Moreover, it significantly decreased the accumulation of fatty droplets in liver tissue, suggesting a protective effect against HFD-induced hepatic steatosis. Dietary supplementation with CSE reversed the HFD-induced decrease in the phosphorylation levels of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), which are related to fatty acid β-oxidation, in the epididymal adipose tissue. Also, CSE increased AMPK and ACC phosphorylation in mature 3T3-L1 adipocytes. CSE also enhanced lipolysis by phosphorylation of cAMP-dependent protein kinase (PKA) and hormone-sensitive lipase (HSL) in mature 3T3-L1 adipocytes. These results suggest that CSE had an antiobesity effect via elevated β-oxidation and lipolysis in adipose tissue. |
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Authors:
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Seong-Il Kang; Hye-Sun Shin; Hyo-Min Kim; Youn-Suk Hong; Seon-A Yoon; Seung-Woo Kang; Jeong-Hwan Kim; Moo-Han Kim; Hee-Chul Ko; Se-Jae Kim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 35 ISSN: 1347-5215 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 223-30 Citation Subset: IM |
Affiliation:
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Department of Biology, Jeju National University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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