Document Detail

Imipramine-induced hyperpigmentation: a case report and review of the literature.
MedLine Citation:
PMID:  19519613     Owner:  NLM     Status:  MEDLINE    
Imipramine-induced hyperpigmentation is rare with only 13 cases reported in the literature to date. We report a 64-year-old female who presented with blue-gray discoloration on her face present for 4-5 years. The patient's medications included imipramine for depression for approximately 23 years. Physical examination revealed slate-gray hyperpigmented discrete and coalescing macules of the malar cheeks and the bilateral temples and periorbitally. She also had diffuse gray pigmentation of the bilateral dorsal hands. Histologic examination revealed an unremarkable epidermis with golden-brown round globules clustered in the superficial dermis, which stained strongly positive with a Fontana-Masson stain. Prussian blue stain for hemosiderin was negative. A diagnosis of imipramine-induced hyperpigmentation was made. Imipramine-induced hyperpigmentation as well as a detailed review of drug-induced hyperpigmentation is discussed.
Mark L D'Agostino; Jessica Risser; Leslie Robinson-Bostom
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  36     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-12     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  799-803     Citation Subset:  IM    
Copyright Information:
(c) 2008 John Wiley & Sons A/S.
Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
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MeSH Terms
Antidepressive Agents, Tricyclic / administration & dosage,  adverse effects*
Dermis / pathology
Imipramine / administration & dosage,  adverse effects*
Middle Aged
Pigmentation Disorders / chemically induced*,  pathology*
Time Factors
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 50-49-7/Imipramine

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