| Imipramine-induced hyperpigmentation: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 19519613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Imipramine-induced hyperpigmentation is rare with only 13 cases reported in the literature to date. We report a 64-year-old female who presented with blue-gray discoloration on her face present for 4-5 years. The patient's medications included imipramine for depression for approximately 23 years. Physical examination revealed slate-gray hyperpigmented discrete and coalescing macules of the malar cheeks and the bilateral temples and periorbitally. She also had diffuse gray pigmentation of the bilateral dorsal hands. Histologic examination revealed an unremarkable epidermis with golden-brown round globules clustered in the superficial dermis, which stained strongly positive with a Fontana-Masson stain. Prussian blue stain for hemosiderin was negative. A diagnosis of imipramine-induced hyperpigmentation was made. Imipramine-induced hyperpigmentation as well as a detailed review of drug-induced hyperpigmentation is discussed. |
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Authors:
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Mark L D'Agostino; Jessica Risser; Leslie Robinson-Bostom |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of cutaneous pathology Volume: 36 ISSN: 1600-0560 ISO Abbreviation: J. Cutan. Pathol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-12 Completed Date: 2009-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425124 Medline TA: J Cutan Pathol Country: Denmark |
Other Details:
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Languages: eng Pagination: 799-803 Citation Subset: IM |
Copyright Information:
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(c) 2008 John Wiley & Sons A/S. |
Affiliation:
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Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA. mark_dagostino@brown.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antidepressive Agents, Tricyclic
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administration & dosage,
adverse effects* Dermis / pathology Female Humans Imipramine / administration & dosage, adverse effects* Middle Aged Pigmentation Disorders / chemically induced*, pathology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Tricyclic; 50-49-7/Imipramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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