| Iminosugars past, present and future: medicines for tomorrow. | |
| | |
MedLine Citation:
|
PMID: 20817006 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Iminosugars comprise the most attractive class of carbohydrate mimetics reported to date and are ideally positioned to take advantage of our increasing understanding of glycobiology in the search for new medicines. First-generation iminosugar drugs suffered from lack of adequate selectivity, resulting in considerable side-effects in the clinic. Current efforts directed towards second-generation compounds, encompassing a much greater range of structures and addressing a wider selection of biochemical targets, are enabling the identification and development of suitable candidates that benefit from improved activity and selectivity. Furthermore, second-generation compounds can address a variety of established targets that have previously proved refractory to other compound classes. This review focuses on the breadth of opportunities provided by second-generation leads from iminosugars (Seglins™). |
| | |
Authors:
|
Graeme Horne; Francis X Wilson; Jon Tinsley; David H Williams; Richard Storer |
Related Documents
:
|
17954456 - The lesbian community and ftms: détente in the butch/ftm borderlands. 285626 - Induction of general anesthesia with diazepam or thiopental: a comparison of the cardio... 11516576 - The history of italian parasitology. 6720816 - Angioid streaks associated with hereditary spherocytosis. 11489106 - The clinical and educational experiences of pre-registration house officers in general ... 22415506 - A survey of trauma registrars: job requirements, responsibilities, recruitment, and ret... |
Publication Detail:
|
Type: Journal Article Date: 2010-09-21 |
Journal Detail:
|
Title: Drug discovery today Volume: 16 ISSN: 1878-5832 ISO Abbreviation: Drug Discov. Today Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9604391 Medline TA: Drug Discov Today Country: England |
Other Details:
|
Languages: eng Pagination: 107-18 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Summit Plc(1), 91 Milton Park, Abingdon, Oxon, OX14 4RY, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: BACE: Therapeutic target and potential biomarker for Alzheimer's disease.
Next Document: Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fib...