Document Detail


Imidazole-substituted analogues of TRH limit behavioral deficits after experimental brain trauma.
MedLine Citation:
PMID:  8411214     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Treatment with thyrotropin releasing hormone (TRH) or TRH analogues improves outcome after experimental brain or spinal cord trauma. TRH analogues with modifications at the N-terminal position of the tripeptide are effective, whereas analogues with modifications of the C-terminal residue are not. Imidazole-substituted TRH analogues, which modify the middle amino acid (histidine) of the tripeptide, have more recently been developed but have not been evaluated in models of central nervous system (CNS) trauma. In the present studies two imidazole-substituted analogues--4(5)-NO2(Im)TRH and 2,4 diiodo(Im)TRH--are shown to improve behavioral recovery following fluid percussion-induced traumatic brain injury (TBI) in rats. Because 4(5)-NO2(Im)TRH has little endocrine activity and 2,4 diiodo(Im)TRH has minimal cardiovascular effects, these experiments support the hypothesis that the neuroprotective actions of TRH analogues are independent of their endocrine or autonomic actions.
Authors:
A I Faden; V M Labroo; L A Cohen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurotrauma     Volume:  10     ISSN:  0897-7151     ISO Abbreviation:  J. Neurotrauma     Publication Date:  1993  
Date Detail:
Created Date:  1993-11-09     Completed Date:  1993-11-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-8     Citation Subset:  IM    
Affiliation:
Department of Neurology, Georgetown University Medical Center, Washington, DC.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Behavior, Animal / drug effects*
Brain Injuries / physiopathology,  psychology*
Imidazoles / pharmacology
Male
Molecular Sequence Data
Rats
Rats, Sprague-Dawley
Thyrotropin-Releasing Hormone / analogs & derivatives*,  pharmacology*
Grant Support
ID/Acronym/Agency:
R49/CCR306634-02//PHS HHS
Chemical
Reg. No./Substance:
0/Imidazoles; 0/thyrotropin-releasing hormone, 2,4-diiodoimidazole-; 0/thyrotropin-releasing hormone, 4(5)-nitroimidazole-; 24305-27-9/Thyrotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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