| Imidazole-substituted analogues of TRH limit behavioral deficits after experimental brain trauma. | |
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MedLine Citation:
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PMID: 8411214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment with thyrotropin releasing hormone (TRH) or TRH analogues improves outcome after experimental brain or spinal cord trauma. TRH analogues with modifications at the N-terminal position of the tripeptide are effective, whereas analogues with modifications of the C-terminal residue are not. Imidazole-substituted TRH analogues, which modify the middle amino acid (histidine) of the tripeptide, have more recently been developed but have not been evaluated in models of central nervous system (CNS) trauma. In the present studies two imidazole-substituted analogues--4(5)-NO2(Im)TRH and 2,4 diiodo(Im)TRH--are shown to improve behavioral recovery following fluid percussion-induced traumatic brain injury (TBI) in rats. Because 4(5)-NO2(Im)TRH has little endocrine activity and 2,4 diiodo(Im)TRH has minimal cardiovascular effects, these experiments support the hypothesis that the neuroprotective actions of TRH analogues are independent of their endocrine or autonomic actions. |
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Authors:
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A I Faden; V M Labroo; L A Cohen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neurotrauma Volume: 10 ISSN: 0897-7151 ISO Abbreviation: J. Neurotrauma Publication Date: 1993 |
Date Detail:
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Created Date: 1993-11-09 Completed Date: 1993-11-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8811626 Medline TA: J Neurotrauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 101-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, Georgetown University Medical Center, Washington, DC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Behavior, Animal / drug effects* Brain Injuries / physiopathology, psychology* Imidazoles / pharmacology Male Molecular Sequence Data Rats Rats, Sprague-Dawley Thyrotropin-Releasing Hormone / analogs & derivatives*, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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R49/CCR306634-02//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Imidazoles; 0/thyrotropin-releasing hormone, 2,4-diiodoimidazole-; 0/thyrotropin-releasing hormone, 4(5)-nitroimidazole-; 24305-27-9/Thyrotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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