Document Detail

Imidazole initiates exsheathing of L3 Teladorsagia circumcincta.
MedLine Citation:
PMID:  23043312     Owner:  NLM     Status:  Publisher    
Abstract The infective larvae of Teladorsagia circumcinta have a protective sheath which is lost soon after they reach the rumen of the sheep. Incubation in vitro with 50 mM imidazole caused more than 75% of L3 T. circumcincta to start exsheathing within 2 h. The initiation of exsheathing was less likely at pH 6.2 than at pH 7.8. The apparent pKa of this process was 7.08, similar to that for the conversion of imidazolium+ to imidazole. Both the extent and the initial rate of exsheathing initiation increased with imidazole concentration (the apparent K½ was about 50 mM). The initial rate of exsheathing initiation was stimulated by lactose and maltose, but not by some other carbohydrates, and by propylamine and imidazole acetic acid, but not by histidine.
Simon Brown; Jennifer D Neale; Magnolia Nava-Tirado; Heather V Simpson; Kevin C Pedley; David C Simcock
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  The Journal of parasitology     Volume:  -     ISSN:  1937-2345     ISO Abbreviation:  J. Parasitol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803124     Medline TA:  J Parasitol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a University of Tasmania, School of Human Life Sciences, University of Tasmania.
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