| Imbalanced Production Of Cytokines By T Cells Associates With The Activation/Exhaustion Status Of Memory T Cells In Chronic HIV-1 Infection. | |
| | |
MedLine Citation:
|
PMID: 21902582 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Chronic HIV-1 infection is characterized by immune cell dysfunctions driven by chronic immune activation. Plasma HIV-1 viral load (VL) is closely correlated to disease progression and the level of immune activation. However, the mechanism by which the persistent presence of HIV-1 damages immune cells is still not fully understood. To evaluate how HIV-1 affects disruption of T cell-mediated immune responses during chronic HIV-1 infection we determined the functional profiles of T cells from subjects with chronic HIV-1 infection. We measured the capacity of PBMCs to produce 25 specific cytokines in response to non-specific T cell stimulation, and found that the capacity to produce Th-1 related cytokines (MIP-1α, MIP-1β, RANTES, IFN-γ and MIG), sIL-2R, and IL-17, but not Th-2 related cytokines, was inversely correlated to plasma VL. The capacities to produce these cytokines were interrelated; notably, IL-17 production had a strong direct correlation with production of MIP-1α, MIP-1β, RANTES, and IFN-γ. In both CD4+ and CD8+ T cells, dysfunctional production of cytokines was associated with T-cell activation (CD38 expression) and exhaustion (PD-1 and/or CTLA-4 expression) status of memory subsets. Although the capacity to produce these cytokines was recovered soon after multiple log10 reduction of plasma viral levels by antiretroviral therapy, memory CD8+ T cells remained activated and exhausted after prolonged virus suppression. Our data suggest that HIV-1 levels directly affect the ability of memory T cells to produce specifically Th1- and Th17-related cytokines during chronic HIV-1 infection. |
| | |
Authors:
|
Kaori Nakayama; Hitomi Nakamura; Michiko Koga; Tomohiko Koibuchi; Takeshi Fujii; Toshiyuki Miura; Aikichi Iwamoto; Ai Kawana-Tachikawa |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-9 |
Journal Detail:
|
Title: AIDS research and human retroviruses Volume: - ISSN: 1931-8405 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
the Institute of Medical Science, the University of Tokyo, Division of Infectious Diseases, Tokyo, Japan; nkaori@ims.u-tokyo.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Opportunistic and Other Infections in HIV-infected Children in Latin America Compared to a Similar C...
Next Document: C868T Single Nucleotide Polymorphism and HIV-1 Disease Progression among Post-Partum Women in Kenya.