| Imbalance of renal production between 5-hydroxytryptamine and dopamine in patients with essential hypertension complicated by microalbuminuria. | |
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MedLine Citation:
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PMID: 23382407 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND In the kidney, 5-hydroxytryptamine (5-HT) and dopamine (DA) are formed by the same enzyme, l-aromatic amino acid decarboxylase, but act on renal function and glomerular structure in an opposite direction. The present study was designed to explore whether rates of renal production of 5-HT relative to that of DA are altered in patients with essential hypertension and microalbuminuria. METHODS We measured urinary levels of 5-HT and DA, reflecting renal production of 5-HT and DA as well as 24-hour ambulatory blood pressure and urinary albumin excretion in 82 consecutive untreated, essential hypertensives without overt proteinuria. RESULTS Urinary 5-HT excretion and the ratio of urinary 5-HT to DA were significantly higher in 22 patients with microalbuminuria than in the remaining patients with normoalbuminuria, although urinary DA levels did not differ between the groups. The 24-hour systolic and diastolic blood pressures were also higher in the microalbuminuric group than in the normoalbuminuric group. Multiple regression analysis revealed that urinary 5-HT excretion and 24-hour systolic blood pressure were independently associated with urinary albumin excretion. Furthermore, urinary 5-HT excretion was positively correlated with creatinine clearance as well as blood pressure but tended to be negatively correlated with fractional excretion of sodium. CONCLUSIONS Renal production of 5-HT is enhanced compared with that of DA in essential hypertensives with microalbuminuria. This imbalance may contribute to the genesis of hypertensive glomerular damage. |
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Authors:
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Masayo Hirose; Fumihiro Tomoda; Tsutomu Koike; Hidenori Yamazaki; Maiko Ohara; Hexing Liu; Satoshi Kagitani; Hiroshi Inoue |
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Publication Detail:
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Type: Journal Article Date: 2012-12-28 |
Journal Detail:
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Title: American journal of hypertension Volume: 26 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-02-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 227-33 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, University of Toyama, Toyama, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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