Document Detail

Imbalance in the stress-adaptation system in patients with inflammatory bowel disease.
MedLine Citation:
PMID:  21112918     Owner:  NLM     Status:  In-Data-Review    
Aim: Though inflammatory bowel disease (IBD) is known as a stress-related disorder, basic evidence for this claim is lacking. The current study was performed to investigate the function of the neuroendocrine-immune system as a main pathway in stress response and stress-coping ability and the associations among stress response, stress-coping ability, and disease activity in IBD patients. Method: A questionnaire was administered to obtain information concerning stress state and stress-coping ability (self-efficacy and sense of coherence [SOC]) in 78 IBD patients and 21 healthy volunteers. Blood samples were taken for determining the serum levels of various stress-related hormones and cytokines before and after a calculation stress test. Results: Self-efficacy was significantly decreased in patients, though the degree of perceived stress and SOC did not differ between patients and controls. Basal levels of cortisol did not differ, but levels of adrenocorticotropic hormone, β-endorphin and interleukin (IL)-6 were significantly higher in patients than in controls. In addition, the control group, but not the patient group, demonstrated significant differences in the basal cortisol levels between low and high SOC subgroups and between low and high perceived stress subgroups. Furthermore, IL-6 levels were significantly increased following the calculation stress test in patients only. Conclusion: Results indicate that IBD patients may have skewed neuroendocrine-immune systems and that emotional stress may aggravate the disease. Stress-management interventions might be useful, not only for patients' quality of life (QOL) but also for disease control.
Tsukasa Kuroki; Akihide Ohta; Ryoko Sherriff-Tadano; Emi Matsuura; Tooru Takashima; Ryuichi Iwakiri; Kazuma Fujimoto
Related Documents :
8242448 - Using mixed venous oxygen saturation data to trend overall oxygenation in cardiothoraci...
2742228 - Sepsis and antithrombin iii, prekallikrein, and fibronectin levels in surgical patients.
21355418 - Determination of oxidant stress in plasma of rheumatoid arthritis and primary osteoarth...
12091178 - Microvascular blood flow is altered in patients with sepsis.
22988518 - Primary sclerosing cholangitis associated with elevated immunoglobulin-g4: a preliminar...
24491628 - Idiopathic renal infarction in a previously healthy active duty soldier.
Publication Detail:
Type:  Journal Article     Date:  2010-11-26
Journal Detail:
Title:  Biological research for nursing     Volume:  13     ISSN:  1552-4175     ISO Abbreviation:  Biol Res Nurs     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-11-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815758     Medline TA:  Biol Res Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-8     Citation Subset:  IM; N    
1Hiroshima Graduate School of Health Sciences, Hiroshima-City, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Preliminary Analysis of the Anti-Inflammatory Activity of Essential Oils of Zingiber zerumbet.
Next Document:  Biological mechanisms related to the effectiveness of guided imagery for chronic pain.