Document Detail

Imbalance between production and scavenging of hydroxyl radicals in patients maintained on hemodialysis.
MedLine Citation:
PMID:  16362158     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Reactive oxygen species are as being related to the pathophysiology of endstage renal disease (ESRD). We measured the plasma hydroxyl radical (.OH)-producing ability and .OH-scavenging activity in patients with ESRD to clarify the pathophysiological states involved. METHODS: We used electron spin resonance to measure plasma N-t-butyl-alpha-phenylnitron radical spin adduct (pPBN rsa) as .OH-producing ability and plasma 3,3,5,5-tetramethyl-1-pyrroline-N-oxide radical spin adduct (pM4PO rsa) as .OH-scavenging activity. Oxidative injuries were evaluated by determining oxidised low-density lipoprotein (Ox-LDL). RESULTS: The pPBN rsa of the ESRD patients was lower than that of the controls (1.83 vs 2.94 micromol/g protein). The pM4PO rsa of the ESRD patients was higher than that of the controls (3.85 vs 3.15 mmol L: -ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl hydrogen phosphate] potassium salt (EPC-K1)/g protein). The pPBN rsa and pM4PO rsa were correlated, both in the ESRD patients and in the controls (r = 0.47 and r = 0.53). Ox-LDL was correlated with hemodialysis (HD) duration (r = 0.49) and was negatively correlated with pPBN rsa (r = -0.54), which indicates that oxidative stress was increased as HD therapy was prolonged and suppressed pPBN rsa. CONCLUSIONS: There was an imbalance between .OH-producing ability and .OH-scavenging activity, in the ESRD patients, and this may be responsible for compromising the health of ESRD patients.
Sayuri Shirai; Masayuki Ominato; Takekazu Shimazu; Katuhide Toyama; Goichi Ogimoto; Tomoya Fujino; Takashi Yasuda; Takeo Sato; Teruhiko Maeba; Shigeru Owada; Kenjiro Kimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental nephrology     Volume:  9     ISSN:  1342-1751     ISO Abbreviation:  Clin. Exp. Nephrol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-02-06     Revised Date:  2006-03-01    
Medline Journal Info:
Nlm Unique ID:  9709923     Medline TA:  Clin Exp Nephrol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  310-4     Citation Subset:  IM    
Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Kawasaki, 216-8511, Japan.
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MeSH Terms
Electron Spin Resonance Spectroscopy
Free Radical Scavengers / metabolism
Hydroxyl Radical / metabolism*
Kidney Failure, Chronic / metabolism*,  therapy*
Lipoproteins, LDL / metabolism
Middle Aged
Oxidative Stress / physiology*
Reactive Oxygen Species / metabolism
Renal Dialysis*
Reg. No./Substance:
0/Free Radical Scavengers; 0/Lipoproteins, LDL; 0/Reactive Oxygen Species; 0/oxidized low density lipoprotein; 3352-57-6/Hydroxyl Radical

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