| Imbalance between production and scavenging of hydroxyl radicals in patients maintained on hemodialysis. | |
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MedLine Citation:
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PMID: 16362158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Reactive oxygen species are as being related to the pathophysiology of endstage renal disease (ESRD). We measured the plasma hydroxyl radical (.OH)-producing ability and .OH-scavenging activity in patients with ESRD to clarify the pathophysiological states involved. METHODS: We used electron spin resonance to measure plasma N-t-butyl-alpha-phenylnitron radical spin adduct (pPBN rsa) as .OH-producing ability and plasma 3,3,5,5-tetramethyl-1-pyrroline-N-oxide radical spin adduct (pM4PO rsa) as .OH-scavenging activity. Oxidative injuries were evaluated by determining oxidised low-density lipoprotein (Ox-LDL). RESULTS: The pPBN rsa of the ESRD patients was lower than that of the controls (1.83 vs 2.94 micromol/g protein). The pM4PO rsa of the ESRD patients was higher than that of the controls (3.85 vs 3.15 mmol L: -ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl hydrogen phosphate] potassium salt (EPC-K1)/g protein). The pPBN rsa and pM4PO rsa were correlated, both in the ESRD patients and in the controls (r = 0.47 and r = 0.53). Ox-LDL was correlated with hemodialysis (HD) duration (r = 0.49) and was negatively correlated with pPBN rsa (r = -0.54), which indicates that oxidative stress was increased as HD therapy was prolonged and suppressed pPBN rsa. CONCLUSIONS: There was an imbalance between .OH-producing ability and .OH-scavenging activity, in the ESRD patients, and this may be responsible for compromising the health of ESRD patients. |
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Authors:
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Sayuri Shirai; Masayuki Ominato; Takekazu Shimazu; Katuhide Toyama; Goichi Ogimoto; Tomoya Fujino; Takashi Yasuda; Takeo Sato; Teruhiko Maeba; Shigeru Owada; Kenjiro Kimura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental nephrology Volume: 9 ISSN: 1342-1751 ISO Abbreviation: Clin. Exp. Nephrol. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-19 Completed Date: 2006-02-06 Revised Date: 2006-03-01 |
Medline Journal Info:
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Nlm Unique ID: 9709923 Medline TA: Clin Exp Nephrol Country: Japan |
Other Details:
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Languages: eng Pagination: 310-4 Citation Subset: IM |
Affiliation:
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Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Kawasaki, 216-8511, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Electron Spin Resonance Spectroscopy Female Free Radical Scavengers / metabolism Humans Hydroxyl Radical / metabolism* Kidney Failure, Chronic / metabolism*, therapy* Lipoproteins, LDL / metabolism Male Middle Aged Oxidative Stress / physiology* Reactive Oxygen Species / metabolism Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 0/Lipoproteins, LDL; 0/Reactive Oxygen Species; 0/oxidized low density lipoprotein; 3352-57-6/Hydroxyl Radical |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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