Document Detail


An Imbalance between VEGF and Endostatin Underlies Impaired Angiogenesis in Gastric Mucosa of Aging Rats.
MedLine Citation:
PMID:  23788612     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Gastric mucosa of aging individuals exhibits increased susceptibility to injury and delayed healing. Our previous studies in young rats showed that healing of mucosal injury depends on and is critically dependent on VEGF and angiogenesis. Since angiogenesis in aging gastric mucosa has not been examined before, in this study we examined the extent to which angiogenesis is impaired in gastric mucosa of aging vs. young rats and determined the underlying mechanisms with a focus on mucosal expression of VEGF (pro-angiogenic factor) and endostatin (anti-angiogenic factor). Aging rats had significantly impaired gastric angiogenesis by ~ 12-fold, 5-fold, 4-fold and 3-fold, respectively (vs. young rats; all p < 0.001) 24, 48, 72 and 120 hours following ethanol-induced gastric injury and reduced and delayed healing of mucosal erosions. In gastric mucosa of aging (vs. young) rats at baseline, VEGF expression was significantly reduced, while endostatin levels were significantly increased (p < 0.05 and p < 0.01, respectively). In contrast to young rats, gastric mucosal VEGF levels did not increase following ethanol-induced injury in aging rats. MMP-9 enzyme activity was significantly higher in gastric mucosa of aging vs. young rats both at baseline (2.7-fold) and 24 hours (3.8-fold) after ethanol injury (both p < 0.001). Since endostatin is generated from collagen XVIII by MMP-9, this finding can explain the mechanism of increased endostatin expression in aging gastric mucosa. The above findings demonstrate that reduced VEGF and increased endostatin result in the impaired angiogenesis and delayed injury healing in gastric mucosa of aging rats.
Authors:
Amrita Ahluwalia; Michael K Jones; Xiaoming Deng; Zsusanna Sandor; Sandor Szabo; Andrzej S Tarnawski
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-20
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  -     ISSN:  1522-1547     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1VA Medical Center, Long Beach, CA.
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