| Imatinib induces hypothyroidism in patients receiving levothyroxine. | |
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MedLine Citation:
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PMID: 16198662 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interactions of imatinib with other drugs have been scarcely reported. We report a previously unknown effect of imatinib on levothyroxine therapy. Eleven patients (1 with gastrointestinal stromal tumor and 10 with medullary thyroid carcinoma) received imatinib. Eight had undergone thyroidectomy and used levothyroxine, and 3 had the thyroid in situ. Thyroid function was measured before, during, and within 2 weeks after any change in either imatinib or levothyroxine dosage. We observed symptoms of hypothyroidism in all patients who had undergone thyroidectomy, whereas patients with the thyroid in situ remained clinically and biochemically euthyroid. On average, thyrotropin (INN, thyrotrophin) levels increased to 384% +/- 228% of the upper limit in patients after thyroidectomy, whereas free thyroxine (fT4) and free tri-iodothyronine (fT3) values remained within the reference range (59% +/- 17% of the upper limit for fT4 and 63% +/- 4% of the upper limit for fT3). Clinicians should be aware that hypothyroid subjects receiving imatinib have a high likelihood for increased levothyroxine replacement and should be closely monitored for elevations in thyrotropin indicating worsening hypothyroidism. |
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Authors:
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Jan Willem B de Groot; Bernard A Zonnenberg; John T M Plukker; Winette T A van Der Graaf; Thera P Links |
Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 78 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-03 Completed Date: 2005-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 433-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Endocrinology, University Medical Centre Groningen, Groningen, and Department of Medical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Agents / adverse effects*, pharmacology Carcinoma, Medullary / drug therapy, surgery Drug Synergism Female Gastrointestinal Stromal Tumors / drug therapy Humans Hypothyroidism / chemically induced* Male Middle Aged Piperazines / adverse effects*, pharmacology Pyrimidines / adverse effects*, pharmacology Thyroid Neoplasms / drug therapy, surgery Thyroidectomy Thyrotropin / blood Thyroxine / adverse effects*, blood, pharmacokinetics Triiodothyronine / blood |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Piperazines; 0/Pyrimidines; 152459-95-5/imatinib; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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