| Imaging tumour physiology and vasculature to predict and assess response to heat. | |
| | |
MedLine Citation:
|
PMID: 20388023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The vascular supply of tumours and the tumour microenvironment both play an important role when tumours are treated with hyperthermia. Blood flow is one of the major vehicles by which heat is dissipated thus the vascular supply will influence the ability to heat the tumour. It also influences the type of microenvironment that exists within tumours, and it is now well-established that cells existing in areas of oxygen deficiency, nutrient deprivation and acidic conditions are more sensitive to the effect of hyperthermia. The vascular supply and microenvironment are also affected by hyperthermia. In general, mild heat temperatures transiently improve blood flow and oxygenation, while higher hyperthermia temperatures cause vascular collapse and so increase the adverse microenvironmental conditions. Being able to image these vascular and microenvironmental parameters both before and after heating will help in our ability to predict and assess response. Here we review the various techniques that can be applied to supply this information, especially using non-invasive imaging approaches. |
| | |
Authors:
|
Steffen L Hokland; Thomas Nielsen; Morten Busk; Michael R Horsman |
Related Documents
:
|
3210193 - Modulating the oxygen tension in tumours by hypothermia and hyperbaric oxygen. 146883 - The effects of the perfusion of various solutions on the no-reflow phenomenon in experi... 8981463 - The human cerebellum and temporal information processing--results from a pet experiment. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group Volume: 26 ISSN: 1464-5157 ISO Abbreviation: Int J Hyperthermia Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-04-14 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8508395 Medline TA: Int J Hyperthermia Country: England |
Other Details:
|
Languages: eng Pagination: 264-72 Citation Subset: IM |
Affiliation:
|
Department of Experimental Clinical Oncology, Aarhus University Hospital NBG, Aarhus, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anoxia
/
physiopathology Humans Hyperthermia, Induced* Magnetic Resonance Imaging Microcirculation* Neoplasms / blood supply*, physiopathology, therapy Positron-Emission Tomography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tumour infiltrating host cells and their significance for hyperthermia.
Next Document: Donor hair follicle preservation by partial follicular unit extraction. A method to optimize hair tr...