| Imaging tumor variation in response to photodynamic therapy in pancreatic cancer xenograft models. | |
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MedLine Citation:
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PMID: 20005458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: A treatment monitoring study investigated the differential effects of orthotopic pancreatic cancer models in response to interstitial photodynamic therapy (PDT), and the validity of using magnetic resonance imaging as a surrogate measure of response was assessed. METHODS AND MATERIALS: Different orthotopic pancreatic cancer xenograft models (AsPC-1 and Panc-1) were used to represent the range of pathophysiology observed in human beings. Identical dose escalation studies (10, 20, and 40J/cm) using interstitial verteporfin PDT were performed, and magnetic resonance imaging with T2-weighted and T1-weighted contrast were used to monitor the total tumor volume and the vascular perfusion volume, respectively. RESULTS: There was a significant amount of necrosis in the slower-growing Panc-1 tumor using high light dose, although complete necrosis was not observed. Lower doses were required for the same level of tumor kill in the faster-growing AsPC-1 cell line. CONCLUSIONS: The tumor growth rate and vascular pattern of the tumor affect the optimal PDT treatment regimen, with faster-growing tumors being relatively easier to treat. This highlights the fact that therapy in human beings shows a heterogeneous range of outcomes, and suggests a need for careful individualized treatment outcomes assessment in clinical work. |
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Authors:
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Kimberley S Samkoe; Alina Chen; Imran Rizvi; Julia A O'Hara; P Jack Hoopes; Stephen P Pereira; Tayyaba Hasan; Brian W Pogue |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 76 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-01-08 Revised Date: 2013-06-07 |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 251-9 Citation Subset: IM |
Affiliation:
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Thayer School of Engineering, Dartmouth College, Hanover, NH, USA. samkoe@dartmouth.edu; pogue@dartmouth.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Tumor Contrast Media / diagnostic use Feasibility Studies Humans Magnetic Resonance Imaging / methods* Male Mice Mice, SCID Necrosis Pancreatic Neoplasms / blood supply, drug therapy*, mortality, pathology Photochemotherapy / methods*, mortality Photosensitizing Agents / administration & dosage* Porphyrins / administration & dosage* Radiotherapy Dosage Tumor Burden Xenograft Model Antitumor Assays |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA084203/CA/NCI NIH HHS; P01 CA084203-06A1/CA/NCI NIH HHS; P01CA84203/CA/NCI NIH HHS; R01 CA109558/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Photosensitizing Agents; 0/Porphyrins; 129497-78-5/verteporfin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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