| Imaging the rat brain on a 1.5 T clinical MR-scanner. | |
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MedLine Citation:
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PMID: 10771078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance imaging (MRI) offers a noninvasive technique for studying neurodegenerative events in the rat brain, however, most of the studies are performed on small bore purpose dedicated MR scanners of limited availability and at high cost. The present study explored the feasibility of using a clinical whole body MR-scanner to perform imaging in rat brain and specifically in models of Parkinson's (PD) and Huntington's disease (HD). For that purpose rats were placed into a specially designed PVC device equipped with a flexible surface coil-and T2-weighted spin echo sequences were acquired on a Siemens Magnetom Vision at 1.5 T. In the experimental protocols of PD and HD, animals underwent 6-hydroxydopamine (6-OHDA) and quinolinic acid (QA) injections, respectively and were subsequently grafted with fetal tissue. T2-weighted images showed a small hyperintense area at the 6-OHDA lesion site and a diffuse hyperintensity in the striata with QA lesions. Transplants were seen as a hypointense area surrounded by a hyperintense rim on T1-weighted images. Moreover, disturbances of the blood-brain-barrier and its time of restoration could be monitored. In conclusion, high-resolution in vivo imaging of small animals is feasible with clinical MR-scanners and hence allows the study of various experimental protocols. |
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Authors:
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R Guzman; K O Lövblad; M Meyer; C Spenger; G Schroth; H R Widmer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroscience methods Volume: 97 ISSN: 0165-0270 ISO Abbreviation: J. Neurosci. Methods Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-06-23 Completed Date: 2000-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905558 Medline TA: J Neurosci Methods Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 77-85 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Inselspital, University of Bern, 3010, Bern, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Artifacts Blood-Brain Barrier Brain / anatomy & histology*, pathology Brain Tissue Transplantation / physiology Female Huntington Disease / chemically induced, pathology Image Processing, Computer-Assisted Immunohistochemistry Magnetic Resonance Imaging / instrumentation* Movement / physiology Oxidopamine Parkinson Disease, Secondary / chemically induced, pathology Perfusion Pregnancy Quinolinic Acid / toxicity Rats Rats, Sprague-Dawley Sympathectomy, Chemical Sympatholytics |
| Chemical | |
Reg. No./Substance:
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0/Sympatholytics; 1199-18-4/Oxidopamine; 89-00-9/Quinolinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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