| Imaging and pharmacokinetics of (64)Cu-DOTA-HB22.7 administered by intravenous, intraperitoneal, or subcutaneous injection to mice bearing non-Hodgkin's lymphoma xenografts. | |
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MedLine Citation:
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PMID: 18949521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of the study is to compare the tumor-specific targeting, pharmacokinetics, and biodistribution of (64)Cu-DOTA-HB22.7 when administered to xenograft-bearing mice intravenously (IV), intraperitoneally (IP), and subcutaneously (SQ). PROCEDURES: Mice bearing human non-Hodgkin's lymphoma (NHL) xenografts were injected IV, IP, or SQ with (64)Cu-DOTA-HB22.7. Xenograft targeting was evaluated by micro positron emission tomography (microPET) and confirmed by organ biodistribution studies. Blood measurements of (64)Cu were performed to determine the pharmacokinetics and clearance of (64)Cu-DOTA-HB22.7. RESULTS: (64)Cu-DOTA-HB22.7 demonstrated equivalent tumor targeting within 24-48 h, regardless of the route of administration. Organ biodistribution confirmed tumor-specific targeting. Blood pharmacokinetics demonstrated that (64)Cu-DOTA-HB22.7 accessed the bloodstream after IP and SQ administration to a similar degree as IV administration, albeit at a slower rate. CONCLUSIONS: These findings establish (64)Cu-DOTA-HB22.7 as a potential radioimmunotherapeutic and/or NHL-specific imaging agent. These findings provide evidence that IP and SQ administration can achieve results equivalent to IV administration and may lead to more efficient, reproducible treatment plans for antibody-based therapeutics. |
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Authors:
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Shiloh M Martin; Robert T O'Donnell; David L Kukis; Craig K Abbey; Hayes McKnight; Julie L Sutcliffe; Joseph M Tuscano |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-10-24 |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: 11 ISSN: 1536-1632 ISO Abbreviation: Mol Imaging Biol Publication Date: 2009 Mar-Apr |
Date Detail:
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Created Date: 2009-02-05 Completed Date: 2009-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: United States |
Other Details:
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Languages: eng Pagination: 79-87 Citation Subset: IM |
Affiliation:
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Division of Hematology and Oncology, Department of Internal Medicine, University of California, Davis Cancer Center, Davis, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / administration & dosage, pharmacokinetics* Copper Radioisotopes / administration & dosage, pharmacokinetics* Female Flow Cytometry Immunoconjugates / administration & dosage, pharmacokinetics Injections Lymphoma, Non-Hodgkin / drug therapy*, radionuclide imaging* Mice Mice, Nude Neoplasm Transplantation Positron-Emission Tomography Radiopharmaceuticals / administration & dosage, chemical synthesis, pharmacokinetics* Succinimides / administration & dosage, pharmacokinetics Tissue Distribution Transplantation, Heterologous Xenograft Model Antitumor Assays |
| Grant Support | |
ID/Acronym/Agency:
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R24 CA110804/CA/NCI NIH HHS; R33 CA89706/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Copper Radioisotopes; 0/DOTA-NHS; 0/Immunoconjugates; 0/Radiopharmaceuticals; 0/Succinimides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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