| Imaging patterns and prognosis of patients with gefitinib-related interstitial lung disease. | |
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MedLine Citation:
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PMID: 21961483 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: We aimed to summarize the imaging findings of 25 patients with gefitinib-related interstitial lung disease (ILD), and identify the factors related to prognosis of gefitinib-related ILD in patients with non-small-cell-lung cancer. Materials and methods: Diagnosis of gefitinib-induced ILD by at least two chest radiologists was based on a review and analysis of the chest radiography and CT findings plus clinical data in the medical records. All patients were diagnosed with Stage III - IV non-small-cell carcinoma (adenocarcinoma (n = 24), bronchioalveolar cell carcinoma (n = 1)) and essential clinical data such as gefitinib as first-line use and survival status were recorded and analyzed to determine whether these were prognosis predictors. The imaging findings were classified into four patterns according to the previous largest study in Japan. Results: The 25 chest radiographs were classified as Pattern A (n = 8), Pattern B (n = 3), Pattern C (n = 6), and pattern D (n = 8). Likewise the 23 CT images were classified as pattern A (n = 8; 34.8%), B (n = 3; 13%), C (n = 5; 21.7%), and D (n = 7; 30.4%). The mortality rate was significantly higher in patients with pattern D than in patients with the other patterns. Pattern D imaging findings were also significantly correlated with non first-line use of gefitinib (p = 0.007). Conclusions: We found an increase in mortality rate in patients with gefitinib associated ILD/pattern D compared to other radiological patterns. Familiarity with these imaging patterns can facilitate early and accurate diagnosis and help physicians gauge clinical prognosis of gefitinib-related ILD. |
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Authors:
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M-K Yuan; C-Y Chang; S-C Chang; S-J Chang; G-J Tang; Y-F Wei; Y-C Liu; C-Y Chen; C-J Yu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of clinical pharmacology and therapeutics Volume: 49 ISSN: 0946-1965 ISO Abbreviation: Int J Clin Pharmacol Ther Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423309 Medline TA: Int J Clin Pharmacol Ther Country: Germany |
Other Details:
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Languages: eng Pagination: 587-93 Citation Subset: IM |
Affiliation:
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Department of Radiology, National Yang-Ming University Hospital, Yilan, Department of Chest Medicine, Far Eastern Memorial Hospital, Taipei, Department of Internal Medicine, National Yang-Ming University Hospital, Yilan, Department of Industrial Management and Enterprise Information, Aletheia University, Taipei, E-DA Hospital/I-Shou University, Kaohsiung County, and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. |
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