| Imaging pain modulation by subanesthetic S-(+)-ketamine. | |
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MedLine Citation:
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PMID: 16931688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Little is known about the effects of low-dose S-(+)-ketamine on the cerebral processing of pain. We investigated the effects of subanesthetic IV S-(+)-ketamine doses on the perception of experimental painful heat stimuli. Healthy volunteers were evaluated with functional magnetic resonance imaging (fMRI) while receiving the painful stimuli in conjunction with placebo and increasing doses (0.05, 0.1, 0.15 mg x kg(-1) x h(-1)) of ketamine infusion. Vital variables were monitored and all subjects rated pain intensity and unpleasantness on a numerical rating scale. Alterations in consciousness were measured using a psycho-behavioral questionnaire. Pain unpleasantness declined as ketamine dosage was increased (55.1% decrease, placebo versus 0.15 mg x kg(-1) x h(-1) ketamine). Pain intensity ratings also decreased with increasing ketamine dosage but to a lesser extent (23.1% decrease). During placebo administration, a typical pain activation network (thalamus, insula, cingulate, and prefrontal cortex) was found, whereas decreased pain perception with ketamine was associated with a dose-dependent reduction of pain-induced cerebral activations. Analysis of the dose-dependent ketamine effects on pain processing showed a decreasing activation of the secondary somatosensory cortex (S2), insula and anterior cingulate cortex. This part of the anterior cingulate cortex (midcingulate cortex) has been linked with the affective pain component that underlines the potency of ketamine in modulating affective pain processing. |
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Authors:
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Till Sprenger; Michael Valet; Ralph Woltmann; Claus Zimmer; Rainer Freynhagen; Eberhard F Kochs; Thomas R Tölle; Klaus J Wagner |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 103 ISSN: 1526-7598 ISO Abbreviation: Anesth. Analg. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-25 Completed Date: 2006-09-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 729-37 Citation Subset: AIM; IM |
Affiliation:
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Neurologische Klinik und Poliklinik, Technische Universität München, Germany. sprenger@lrz.tu-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analgesics / pharmacology Brain / drug effects*, pathology Dose-Response Relationship, Drug Hemodynamics Humans Ketamine / pharmacology* Magnetic Resonance Imaging / instrumentation*, methods* Male Pain / drug therapy* Pain Measurement Pilot Projects Placebos |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Placebos; 6740-88-1/Ketamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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