| Imaging of neuroendocrine tumors: accuracy of helical CT versus SRS. | |
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MedLine Citation:
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PMID: 15162235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We retrospectively compared the accuracy of somatostatin receptor scintigraphy (SRS) with that of helical computed tomography (CT) in the detection and localization of primary and metastatic neuroendocrine tumors. METHODS: A medical record search identified 27 patients with known or clinically suspected neuroendocrine tumors who underwent helical CT and SRS within 3 months of one another at our institution. CT images were evaluated retrospectively by two blinded radiologists who used consensus reading. Images were evaluated for the presence or absence of primary tumor and hepatic and extrahepatic metastases. CT results were compared with the SRS report as interpreted by the nuclear medicine physicians. The results of the surgical, clinical follow-up, and pathologic findings were considered as the gold standard. Sensitivity, specificity, and accuracy were calculated for both imaging techniques. In addition, McNemar analysis was performed to determine statistically significant differences between CT and SRS. RESULTS: Helical CT was more sensitive than SRS in the detection of extrahepatic metastases, and the difference between the two imaging modalities was statistically significant (p = 0.0312) as determined by the McNemar chi-square test. However, the difference between CT and SRS in detecting primary neuroendocrine tumors, hepatic metastasis, and combined hepatic and extrahepatic metastasis was not statistically significant (p = 0.625, 1.000, and 1.000, respectively). CONCLUSION: Helical CT and SRS have similar sensitivity, specificity, and accuracy in detecting primary neuroendocrine tumor and hepatic metastasis. However, helical CT appears to be more sensitive in detecting extrahepatic metastasis from primary neuroendocrine tumors. |
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Authors:
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B Kumbasar; I R Kamel; A Tekes; J Eng; E K Fishman; R L Wahl |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2004-05-27 |
Journal Detail:
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Title: Abdominal imaging Volume: 29 ISSN: 0942-8925 ISO Abbreviation: Abdom Imaging Publication Date: 2004 Nov-Dec |
Date Detail:
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Created Date: 2004-11-02 Completed Date: 2005-02-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9303672 Medline TA: Abdom Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 696-702 Citation Subset: IM |
Affiliation:
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Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, 601 North Caroline Street, Baltimore, MD 21287, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma, Islet Cell
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radionuclide imaging Adolescent Adult Aged Female Humans Indium Radioisotopes / diagnostic use Intestinal Neoplasms / radionuclide imaging Liver Neoplasms / secondary Male Middle Aged Neuroendocrine Tumors / radiography*, radionuclide imaging*, secondary Pancreatic Neoplasms / radionuclide imaging Receptors, Somatostatin / analysis* Sensitivity and Specificity Somatostatin / analogs & derivatives*, diagnostic use Tomography, Spiral Computed* |
| Chemical | |
Reg. No./Substance:
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0/Indium Radioisotopes; 0/Receptors, Somatostatin; 138661-02-6/pentetreotide; 51110-01-1/Somatostatin |
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