| Imaging of myocardial viability: a head-to-head comparison among nuclear, echocardiographic, and angiographic techniques. | |
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MedLine Citation:
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PMID: 10146369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between radioisotopic, echocardiographic, and angiographic markers of myocardial viability is still to be defined. To this purpose, 14 patients with previous myocardial infarction were studied using a multiparametric approach. Each patient underwent, on separate days, rest thallium 201 and technetium 99m Sestamibi planar scintigraphy, dobutamine/dipyridamole stress echocardiography, and coronary angiography; 11 of these patients underwent also dipyridamole echocardiographic testing. Thallium 201 and Sestamibi uptakes at rest were expressed as percentage of maximal activity in each projection using a 13 segment model. Dobutamine and dipyridamole stress echocardiography were analyzed using a score index ranging from 1 (normokinesis) to 4 (dyskinesis) and a similar segmentation. Coronary angiography was analyzed by quantitative approach. In all patients, follow-up echocardiography was performed following coronary revascularization. Before revascularization, 75 segments showed regional dyssynergies. Thallium 201 showed the highest sensitivity and specificity in the preoperative identification of viability, whereas Sestamibi was affected by a significant number of false-negative studies. Among echocardiographic techniques, dobutamine was slightly superior to dipyridamole in the detection of viable segments. The degree of coronary stenosis failed to predict the recovery of function following by-pass graft or angioplasty in almost all segments; however, in case of occlusion, most viable segments were perfused by adequately collateralized coronary arteries. |
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Authors:
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P Marzullo; O Parodi; E Picano; G Sambuceti; B Reisenhofer; A Gimelli; A Distante; A L'Abbate |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of cardiac imaging Volume: 7 ISSN: 0887-7971 ISO Abbreviation: Am J Card Imaging Publication Date: 1993 Sep |
Date Detail:
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Created Date: 1993-12-29 Completed Date: 1993-12-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8706659 Medline TA: Am J Card Imaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 143-51 Citation Subset: T |
Affiliation:
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National Research Council Institute of Clinical Physiology, Pisa, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Coronary Angiography / methods* Dipyridamole / diagnostic use Dobutamine / diagnostic use Echocardiography / drug effects, methods* Exercise Test Female Follow-Up Studies Gamma Cameras* Humans Male Middle Aged Myocardial Ischemia / diagnosis*, physiopathology Radionuclide Angiography Sensitivity and Specificity Technetium Tc 99m Sestamibi / diagnostic use Thallium Radioisotopes / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Thallium Radioisotopes; 109581-73-9/Technetium Tc 99m Sestamibi; 34368-04-2/Dobutamine; 58-32-2/Dipyridamole |
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