Document Detail

Imaging multiple sclerosis and other neurodegenerative diseases.
MedLine Citation:
PMID:  23117868     Owner:  NLM     Status:  MEDLINE    
Although the prevalence of neurodegenerative diseases is increasing as a consequence of the growing aging population, the exact pathophysiological mechanisms leading to these diseases remains obscure. Multiple sclerosis (MS), an autoimmune disease of the central nervous system and the most frequent cause of disability among young people after traumatic brain injury, is characterized by inflammatory/demyelinating and neurodegenerative processes that occurr earlier in life. The ability to make an early diagnosis of MS with the support of conventional MRI techniques, provides the opportunity to study neurodegeneration and the underlying pathophysiological processes in earlier stages than in classical neurodegenerative diseases. This review summarizes mechanisms of neurodegeneration common to MS and to Alzheimer disease, Parkinson disease, and amiotrophic lateral sclerosis, and provides a brief overview of the neuroimaging studies employing MRI and PET techniques to investigate and monitor neurodegeneration in both MS and classical neurodegenerative diseases.
Matilde Inglese; Maria Petracca
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-11-01
Journal Detail:
Title:  Prion     Volume:  7     ISSN:  1933-690X     ISO Abbreviation:  Prion     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-08-19     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101472305     Medline TA:  Prion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
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MeSH Terms
Brain / pathology*
Iron / analysis
Magnetic Resonance Imaging / methods*
Microglia / pathology
Mitochondria / pathology
Multiple Sclerosis / diagnosis*,  pathology
Nerve Degeneration / diagnosis,  pathology
Neurodegenerative Diseases / diagnosis*,  pathology
Positron-Emission Tomography / methods*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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