| Imaging mass spectrometry in microbiology. | |
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MedLine Citation:
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PMID: 21822293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Imaging mass spectrometry tools allow the two-dimensional visualization of the distribution of trace metals, metabolites, surface lipids, peptides and proteins directly from biological samples without the need for chemical tagging or antibodies, and are becoming increasingly useful for microbiology applications. These tools, comprising different imaging mass spectrometry techniques, are ushering in an exciting new era of discovery by enabling the generation of chemical hypotheses based on the spatial mapping of atoms and molecules that can correlate to or transcend observed phenotypes. In this Innovation article, we explore the wide range of imaging mass spectrometry techniques that is available to microbiologists and describe the unique applications of these tools to microbiology with respect to the types of samples to be investigated. |
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Authors:
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Jeramie D Watrous; Pieter C Dorrestein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-08-08 |
Journal Detail:
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Title: Nature reviews. Microbiology Volume: 9 ISSN: 1740-1534 ISO Abbreviation: Nat. Rev. Microbiol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-12 Completed Date: 2011-10-19 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 101190261 Medline TA: Nat Rev Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 683-94 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Image Processing, Computer-Assisted
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instrumentation,
methods* Mass Spectrometry / instrumentation, methods* Microbiology / instrumentation* |
| Grant Support | |
ID/Acronym/Agency:
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AI095125/AI/NIAID NIH HHS; GM08283/GM/NIGMS NIH HHS; GM08326/GM/NIGMS NIH HHS; GM094802/GM/NIGMS NIH HHS; R01 AI095125/AI/NIAID NIH HHS; R01 AI095125-02/AI/NIAID NIH HHS; R01 GM086283/GM/NIGMS NIH HHS; R01 GM094802/GM/NIGMS NIH HHS |
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