Document Detail


Imaging mass spectrometry in microbiology.
MedLine Citation:
PMID:  21822293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Imaging mass spectrometry tools allow the two-dimensional visualization of the distribution of trace metals, metabolites, surface lipids, peptides and proteins directly from biological samples without the need for chemical tagging or antibodies, and are becoming increasingly useful for microbiology applications. These tools, comprising different imaging mass spectrometry techniques, are ushering in an exciting new era of discovery by enabling the generation of chemical hypotheses based on the spatial mapping of atoms and molecules that can correlate to or transcend observed phenotypes. In this Innovation article, we explore the wide range of imaging mass spectrometry techniques that is available to microbiologists and describe the unique applications of these tools to microbiology with respect to the types of samples to be investigated.
Authors:
Jeramie D Watrous; Pieter C Dorrestein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-08-08
Journal Detail:
Title:  Nature reviews. Microbiology     Volume:  9     ISSN:  1740-1534     ISO Abbreviation:  Nat. Rev. Microbiol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-12     Completed Date:  2011-10-19     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  101190261     Medline TA:  Nat Rev Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  683-94     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Image Processing, Computer-Assisted / instrumentation,  methods*
Mass Spectrometry / instrumentation,  methods*
Microbiology / instrumentation*
Grant Support
ID/Acronym/Agency:
AI095125/AI/NIAID NIH HHS; GM08283/GM/NIGMS NIH HHS; GM08326/GM/NIGMS NIH HHS; GM094802/GM/NIGMS NIH HHS; R01 AI095125/AI/NIAID NIH HHS; R01 AI095125-02/AI/NIAID NIH HHS; R01 GM086283/GM/NIGMS NIH HHS; R01 GM094802/GM/NIGMS NIH HHS; T32 GM008326/GM/NIGMS NIH HHS
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