Document Detail

Imaging macrophages in trehalose with SIMS.
MedLine Citation:
PMID:  20428458     Owner:  NLM     Status:  Publisher    
Phagocytosis is a major component of the animal immune system where apoptotic cellular material, metabolites, and waste are safely processed. Further, efficient phagocytosis by macrophages is key to maintaining healthy vascular systems and preventing atherosclerosis. Single-cell images of macrophage phagocytosis of red blood cells, RBCs, and polystyrene microspheres have been chemically mapped with TOF-SIMS. We demonstrate here cholesterol and phosphocholine localizations as relative to time and activity.
S A Parry; M E Kurczy; X Fan; M S Halleck; R A Schlegel; N Winograd
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Publication Detail:
Journal Detail:
Title:  Applied surface science     Volume:  255     ISSN:  0169-4332     ISO Abbreviation:  -     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2010-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101307063     Medline TA:  Appl Surf Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  929-933     Citation Subset:  -    
Department of Chemistry, University Park, PA 16802, United States.
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Grant Support
R01 EB002016-13//NIBIB NIH HHS

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