Document Detail

Imaging of macroaneurysms occurring during retinal vein occlusion and diabetic retinopathy by indocyanine green angiography and high resolution optical coherence tomography.
MedLine Citation:
PMID:  19701812     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Macular edema occurring after retinal vein occlusion (RVO) or diabetic retinopathy (DR) may be due to the development of capillary and/or venous macroaneurysms (MAs). Here, we investigated the respective contribution of fluorescein angiography (FA), of indocyanine green angiography (ICGA) and of high-resolution optical coherence tomography (HR-OCT) to their detection. METHODS: Review of the charts of six consecutive patients with MAs secondary to RVO (n = 4) or DR (n = 2). For each patient, FA, ICGA and HR-OCT data were analyzed and compared. RESULTS: All detectable MAs were detected by ICGA, while in three eyes FA failed to show them. Overall, ICGA provided a better delineation of MAs than FA. In all cases, HR-OCT identified MAs under the form of a vascular structure with a reflective wall surrounding a lumen containing variably reflective material. CONCLUSIONS: MAs can develop during the course of RVO and DR. ICGA and HR-OCT improves the identification of capillary and venous MAs, and may thus be of interest to better identify sites of blood-retinal barrier rupture during chronic macular edema due to RVO or DR.
Alexandre Bourhis; Jean-Fran?ois Girmens; Severin Boni; Florence Pecha; Catherine Favard; Jos?-Alain Sahel; Michel Paques
Publication Detail:
Type:  Journal Article     Date:  2009-08-25
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv f?r klinische und experimentelle Ophthalmologie     Volume:  248     ISSN:  1435-702X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-05     Completed Date:  2010-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  161-6     Citation Subset:  IM    
Department of Ophthalmology of the Fondation Ophtalmologique Rothschild, Universit? Pierre et Marie Curie Paris6, 75019 Paris, France.
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MeSH Terms
Aneurysm / etiology,  pathology*
Angiography / methods*
Coloring Agents / diagnostic use
Diabetic Retinopathy / complications,  pathology*
Fluorescein Angiography
Indocyanine Green / diagnostic use
Macular Edema / etiology,  pathology
Middle Aged
Retinal Vein Occlusion / complications,  pathology*
Retinal Vessels / pathology
Tomography, Optical Coherence / methods*
Reg. No./Substance:
0/Coloring Agents; 3599-32-4/Indocyanine Green

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