|Imaging lung disease in systemic sclerosis.|
|Jump to Full Text|
|PMID: 20425026 Owner: NLM Status: MEDLINE|
|Interstitial lung disease and pulmonary hypertension (PH) are the most common cardiopulmonary findings in patients with systemic sclerosis (SSc). About two thirds of patients suffering from SSc develop scleroderma interstitial lung disease. PH is present in about 20% of SSc patients and is typically associated with severe lung disease, although it may be an isolated manifestation of SSc. High-resolution CT scanning is a key method for evaluating chest involvement. There are four roles of imaging in scleroderma interstitial lung disease: 1) detection of lung involvement, 2) identification of patients likely to respond to treatment, 3) assessment of treatment efficacy, and 4) exclusion of other significant diseases to include PH and cardiac and esophageal abnormalities.|
|Diane Strollo; Jonathan Goldin|
Related Documents :
|11787856 - Severe bronchiolitis in acute mycoplasma pneumoniae infection.
3673466 - A critical evaluation of bronchoalveolar lavage. criteria for identifying unsatisfactor...
22970406 - Lysosomal fusion dysfunction as a unifying hypothesis for alzheimer's disease pathology.
21071376 - Pulmonary sarcoidosis: typical and atypical manifestations at high-resolution ct with p...
16167406 - Ethics and infectious disease.
18322926 - Chemotoxicity recovery of mitochondria in non-hodgkin lymphoma resulting in minimal res...
|Type: Journal Article; Research Support, N.I.H., Extramural; Review|
|Title: Current rheumatology reports Volume: 12 ISSN: 1534-6307 ISO Abbreviation: Curr Rheumatol Rep Publication Date: 2010 Apr|
|Created Date: 2010-04-28 Completed Date: 2010-07-22 Revised Date: 2010-09-30|
Medline Journal Info:
|Nlm Unique ID: 100888970 Medline TA: Curr Rheumatol Rep Country: United States|
|Languages: eng Pagination: 156-61 Citation Subset: IM|
|Department of Radiology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA. email@example.com|
|APA/MLA Format Download EndNote Download BibTex|
Hypertension, Pulmonary / diagnosis*, epidemiology, physiopathology
Lung Diseases, Interstitial / diagnosis*, epidemiology, physiopathology
Scleroderma, Systemic / diagnosis*, epidemiology, physiopathology
Tomography, X-Ray Computed
Journal ID (nlm-ta): Curr Rheumatol Rep
Publisher: Current Science Inc., New York
? The Author(s) 2010
Electronic publication date: Day: 16 Month: 3 Year: 2010
pmc-release publication date: Day: 16 Month: 3 Year: 2010
Print publication date: Month: 4 Year: 2010
Volume: 12 Issue: 2
First Page: 156 Last Page: 161
PubMed Id: 20425026
Publisher Id: 95
|Imaging Lung Disease in Systemic Sclerosis|
1Department of Radiology, University of Pittsburgh Medical Center, 200 Lothrop St, PUH, E-177, Pittsburgh, PA 15213 USA
2Department of Radiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095-1721 USA
Systemic sclerosis (SSc), or scleroderma, is a chronic multisystem disorder of small vessels and connective tissues characterized by diffuse fibrosis of the skin and internal organs, most frequently the lungs and gastrointestinal tract. The disease has a 3:1 female predilection and typically occurs in the third to fifth decades of life. Almost all patients have skin involvement. Up to 80% of patients have limited cutaneous disease, which typically has an insidious onset and skin changes confined to the face and extremities, whereas 20% with diffuse involvement may have more severe and rapidly progressive skin, lung, cardiac, and gastrointestinal disease . Patients with interstitial lung disease (ILD) and pulmonary vascular disease may be severely symptomatic due to restrictive lung physiology and low diffusing capacity. Esophageal dysmotility occurs in almost all SSc patients, and gastroesophageal reflux may mimic or overlap with ILD. Cardiac involvement, to include right heart dysfunction due to pulmonary hypertension (PH), myocardial fibrosis, and pericardial involvement, may further compound pulmonary symptoms.
ILD and PH are the most common cardiopulmonary findings in SSc [2, 3]. About two thirds of patients suffering from SSc develop scleroderma ILD (SILD) [4?6]. PH is present in about 20% of SSc patients and is typically associated with severe pulmonary disease, although it may be an isolated manifestation of SSc . Currently, SILD is the leading cause of death in SSc patients, due to pulmonary fibrosis with or without PH. The mortality rate from SILD is about 40% within 10?years after the onset of the disease [7?9].
There are four key roles of imaging in ILD related to SSc: 1) detection of lung involvement, 2) identification of patients likely to respond to treatment, 3) assessment of treatment efficacy, and 4) exclusion of other significant diseases to include PH and cardiac and esophageal abnormalities.
Chest radiography is highly insensitive in detecting and assessing the extent of lung involvement in SSc patients . In fact, patients with pulmonary symptoms and early lung involvement may have a normal chest radiograph. Radiographic findings of SILD are observed in up to two thirds of symptomatic patients, whereas pulmonary fibrosis is detected in only 25% to 44% . SILD typically manifests as low lung volume and predominantly increased ground glass opacity (GGO) and reticular interstitial thickening that is greatest in the lung bases. Advanced cases with pulmonary fibrosis may exhibit traction bronchiectasis and honeycomb cystic change. However, some patients with pulmonary fibrosis may have subtle radiographic findings [10, 11].
High-resolution CT (HRCT) has been shown to be more accurate than chest radiography in detecting and characterizing diffuse lung diseases, and abnormalities on CT correlate more closely with pulmonary function test (PFT) abnormalities [12?14]. HRCT is now well-established as a sensitive and noninvasive means of detecting and characterizing SILD [15?19]. CT features of fibrosis are present in 55% to 65% of all patients with SSc and in up to 96% of those with abnormal PFT results [5, 11, 13, 14, 17, 19, 20]. As a result, HRCT has become an important part of the routine evaluation of SILD. Classically, the disease affects juxtapleural, posterior, and basilar portions of the lungs, with initially subtle alterations of increased GGO, defined as increased lung attenuation in the absence of architectural distortion, as well as accentuated reticular markings that may progress to pulmonary fibrosis, defined as architectural distortion with reticular intralobular interstitial thickening, traction bronchiectasis and bronchiolectasis, and honeycomb cystic change (Figs.?1 and 2). These hallmark CT features of SILD are similar to those of idiopathic, nonspecific interstitial pneumonitis (NSIP). A similar association has been reported in radiologic-pathologic correlations of surgical lung biopsy specimens of patients with SSc [20?23].
SILD typically manifests on CT as predominantly GGO with an admixture of pulmonary fibrosis consistent with the NSIP pattern. Honeycomb cystic changes are reported in 11% to 37% of patients with SILD. This is unlike other patients with NSIP, who have little or no cystic change [23?25]. As honeycomb cystic change is typically a marker for usual interstitial pneumonia (UIP) and pulmonary fibrosis , these findings suggest that patients with SILD disease may have a mixture (or overlap) of UIP and NSIP patterns. This is consistent with the findings of Desai et al.  and other autopsy studies, in which typical histopathologic findings of SILD included marked pulmonary fibrosis and honeycomb cystic change [24, 27, 28].
It has been incorrectly assumed that SILD is more common and severe in patients with diffuse cutaneous systemic sclerosis (dcSSc). In several recent studies, about 40% of patients with pulmonary involvement have demonstrated cutaneous systemic sclerosis (lcSSc) [8, 9, 29, 30??]. In the recent Scleroderma Lung Study, lcSSc and dcSSc patients were indistinguishable with regard to their baseline pulmonary functions, but lcSSc patients presented with more extensive pulmonary fibrosis, possibly reflecting a delay in diagnosis and progression of lung disease prior to study entry [30??]. The rate of progression of SILD is similar in lcSSc and dcSSc patients after adjustment for baseline differences in the degree of pulmonary fibrosis. Given that baseline forced vital capacity and pulmonary fibrosis scores were the most important independent predictors of the decline in pulmonary function over time in Scleroderma Lung Study patients, all SSc patients should be evaluated carefully for lung involvement irrespective of disease extent .
Criteria have been developed for scoring the severity and extent of SILD disease based on disease distribution, relative proportions of reticulations and GGO, and presence of fibrosis on CT scans at one or more levels throughout the chest. These can be based on visual or computer-based quantification schema. Visual scoring systems typically divide each lung into three zones (lung apex to aortic arch, aortic arch to inferior pulmonary veins, inferior pulmonary veins to lung bases), and the extent of lung abnormality in each zone is scored on a scale of 0?4 (0 = absent; 1?=?1%?25%; 2?=?26%?50%; 3?=?51%?75%; 4?=?76%?100%) . More recently, a simplified scoring system based on whether more or less than 25% of the lung is affected has been suggested [32??]. Computer-based approaches also have been investigated and are based on measurement of the density or texture features of each pixel and assignment of a measure of the amount of abnormal lung tissue present. Computer-based models correlate well with visual scoring techniques for the detection of fibrosis (area under the curve = 0.86) and with the assessment of extent of disease (area under the curve = 0.96 for estimating lung involvement >25%) without the intrareader variation encountered with visual scoring .
HRCT scanning has been used to predict outcome in addition to characterizing the nature and extent of SILD [34?36]. The absence of lung disease at an initial CT evaluation is a superior predictor of excellent long-term prognosis with regard to SILD. In a serial HRCT study of 90 SSc patients, 40 had no evidence of pulmonary fibrosis on an initial scan; of these 40, 35 (88%) continued to have a normal HRCT scan at follow-up for an average of 5?years . Because many SSc patients have limited pulmonary fibrosis that may not necessarily progress, the decision to start treatment is often a clinical challenge. The estimation of disease extent (using HRCT) and severity (using PFT) is pivotal. Careful prognostic evaluation, including the staging of disease severity and the definition of longitudinal disease behavior (by serial imaging and PFT), is central to the formulation of a logical management plan .
It is now well-established that GGO is not indicative of active inflammation and likely represents microscopic pulmonary fibrosis that is below the resolution of CT. Previously, the presence of GGO in the absence of associated architectural distortion was thought to represent underlying inflammation, or ?alveolitis,? and to predict a high likelihood of reversible lung disease in SSc, based on studies in other diffuse lung diseases . Recent studies have shown that at best, a weak relationship between GGO and abnormal bronchoalveolar lavage evidence for active lung inflammation . Furthermore, the limitations of GGO as a predictive marker of active or reversible inflammation have been reinforced by longitudinal studies of CT change with and without treatment. When reticular interstitial abnormalities are present, as in most SSc cases, regression of disease on CT occurs in only a minority of patients in the short term . In the long term, GGO usually progresses to overt fibrosis . In a recent serial study of 41 SSc patients, GGO that occurred in two thirds of the cases regressed in only 5% during the following 2?years and was often resistant to treatment . Thus, the postulated relationship between GGO and active inflammation/alveolitis in SILD has been largely discredited.
More recently, the findings of fibrosis on HRCT scans of patients with SILD have been shown to be a useful predictor of the progression of fibrosis when untreated and of a favorable response to treatment with cyclophosphamide compared with placebo . The extent of pulmonary fibrosis on CT also has played a key role in determining the prognosis of patients with SSc [32??]. In a study of 215 patients, those with more extensive disease on HRCT (i.e., abnormalities involving >20% of the lung volume) had strikingly higher mortality and rapid decline of lung function, whereas patients with less than 20% abnormality had no increase in long-term mortality compared with SSc patients with a normal HRCT [32??]. To overcome the difficulties in formally scoring disease extent on HRCT in routine practice, the authors proposed a simple semiquantitative staging system of limited and extensive disease, in which CT evaluation and forced vital capacity values are integrated.
Experience is limited with the use of HRCT as an outcome measure in therapeutic trials. HRCT scanning has been used only infrequently in a prospective, systematic manner as an outcome parameter for assessing therapeutic responses in patients with SILD [39?43]. The validity of serial CT studies is also compromised by the difficulty in achieving exact anatomic comparability between initial and follow-up CT scans, which is due to inherent differences in HRCT slice acquisitions. Low-dose volume (spiral) acquisition CT techniques may overcome this problem, and several studies are under way. In contrast, when anatomic comparability is achieved, it may be difficult to ascertain the clinical significance of minor CT changes that are confined to limited lung regions. The recent serial study of Launay et al.  was limited by their definition of change in lung involvement by more or less than 50% of the lung volume. This system may fail to identify significant change in many cases in which the arbitrary threshold of 50% is not crossed. In a more recent study, when readers graded SILD on serial HRCT as worsened, unchanged, or improved, there was an excellent correlation among CT changes, patient outcome, and treatment efficacy that was only marginal as suggested by conventional pulmonary function criteria .
PH, defined as pulmonary artery pressure greater than 35?mm Hg as estimated by transesophageal echocardiography, affects about 20% (range, 6%?60%) of patients with SSc [2, 3] and is a major cause of SSc-related death [44??]. When complicated by PH, systemic sclerosis has a very poor prognosis. About half of patients with PH develop the disease within 5?years of the SSc diagnosis [44??]. Primary cardiac involvement from SSc may smolder for years before manifesting as overt cardiomyopathy, pericardial disease, or conduction abnormalities . SSc heart disease has a poor prognosis and may be related to excessive deposition of abnormal collagen that impairs myocardial contractility, and to ischemia from coronary vasculopathy .
Scleroderma involves the gastrointestinal tract in up to 90% of patients, and fibrosis and atrophy may result in motility disorders. Esophageal involvement is often an early and asymptomatic manifestation of SSc. A dilated esophagus containing fluid, gas, and/or debris in the setting of SSc reflects esophageal involvement and may help differentiate ILD due to connective tissue disease from other etiologies (Fig.?3). Asymptomatic esophageal dilatation and esophageal dysmotility are detected in up to 80% of patients . Gastroesophageal reflux may play a role in the development and/or progression of SILD [48, 49]. Early detection and treatment of esophageal involvement may forestall complications, which include chronic reflux, aspiration pneumonia, Barrett?s esophagus, and esophageal stricture and malignancy.
The presence of mediastinal lymph node enlargement in patients with SILD is relatively higher than other causes of ILD and has been reported in up to 60% of cases . Nodal enlargement typically corresponds to reactive change on histopathology when biopsy is performed.
Scleroderma is a systemic disorder of connective tissues and vasculopathy that involves multiple organ systems, typically the skin, esophagus, and lungs. Symptoms of ILD may frequently overlap with those of PH, aspiration pneumonia, and cardiomyopathy. As patients with limited and diffuse cutaneous scleroderma may exhibit progressive and extensive pulmonary fibrosis, all scleroderma patients should be evaluated for lung involvement. Histopathologic assessment of SILD typically represents overlapping features with NSIP and UIP.
HRCT, in conjunction with PFT results, plays a critical role in the detection and treatment of SILD and in the prediction of outcomes. Visual scoring and computer-based HRCT techniques are comparable in detecting and grading disease severity and progression. On CT, SILD typically manifests as GGO and accentuated reticulations that may progress to pulmonary fibrosis. GGO was recently discredited as a marker of active inflammation and reversible lung injury.
Dr. Goldin has received funding from the National Institutes of Health.
Disclosure Dr. Goldin is the director of MedQIA. No other potential conflicts of interest relevant to this article were reported.
Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
|1..||Kreig T,Takehara K. Skin disease: a cardinal feature of systemic sclerosisRheumatology (Oxford)Year: 200948Suppl 3iii14iii1810.1093/rheumatology/kep10819487217|
|2..||Silver RM,Miller KS. Lung involvement in systemic sclerosisRheum Dis Clin North AmYear: 1990161992162406808|
|3..||Ramirez A,Varga J. Pulmonary arterial hypertension in systemic sclerosis: clinical manifestations, pathophysiology, evaluation, and managementTreat Respir MedYear: 2004333935210.2165/00151829-200403060-0000215658881|
|4..||Gilliland BC,et al. Braunwald E,Fauci AS,Kasper DL,et al.Systemic sclerosis (scleroderma)Harrison?s Principles of Internal MedicineYear: 200115New YorkMcGraw-Hill|
|5..||Arroliga AC,Podell DN,Matthay RA. Pulmonary manifestations of sclerodermaJ Thorac ImagingYear: 19927304510.1097/00005382-199203000-000051578524|
|6..||Ungerer RG,Tashkin DP,Furst D,et al. Prevalence and clinical correlates of pulmonary arterial hypertension in progressive systemic sclerosisAm J MedYear: 198375657410.1016/0002-9343(83)91169-56859087|
|7..||Mukerjee D,St George D,Coleiro B,et al. Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approachAnn Rheum DisYear: 2003621088109310.1136/ard.62.11.108814583573|
|8..||Steen VD,Conte C,Owens GR,Medsger TA Jr. Severe restrictive lung disease in systemic sclerosisArthritis RheumYear: 1994371283128910.1002/art.17803709037945490|
|9..||White B,Moore WC,Wigley FM,et al. Cyclophosphamide is associated with pulmonary function and survival benefit in patients with scleroderma and alveolitisAnn Intern MedYear: 200013294795410858177|
|10..||Bianchi FA,Bistue AR,Wendt VE,et al. Analysis of twenty-seven cases of progressive systemic sclerosis and a review of the literatureJ Chronic DisYear: 19661995397710.1016/0021-9681(66)90030-05966290|
|11..||Schurawitzki H,Stiglbauer R,Graninger W,et al. Interstitial lung disease in progressive systemic sclerosis: high resolution CT versus radiographyRadiologyYear: 19901767557592389033|
|12..||Swensen SJ,Aughenbaugh GL,Myers JL. Diffuse lung disease: diagnostic accuracy of CT in patients undergoing surgical biopsy of the lungRadiologyYear: 19972052292349314990|
|13..||Remy-Jardin M,Remy J,Wallaert B,et al. Pulmonary involvement in progressive systemic sclerosis: sequential evaluation with CT, pulmonary function tests, and bronchoalveolar lavageRadiologyYear: 19931884995068327704|
|14..||Diot E,Boissinot E,Asquier E,et al. Relationship between abnormalities on high-resolution CT and pulmonary function in systemic sclerosisChestYear: 19981141623162910.1378/chest.114.6.16239872198|
|15..||Launay D,Remy-Jardin M,Michon-Pasturel U,et al. High resolution computed tomography in fibrosing alveolitis associated with systemic sclerosisJ RheumatolYear: 2006331789180116960939|
|16..||Desai SR,Veeraraghavan S,Hansell DM,et al. CT features of lung disease in patients with systemic sclerosis: comparison with idiopathic pulmonary fibrosis and nonspecific interstitial pneumoniaRadiologyYear: 200423256056710.1148/radiol.232203122315286324|
|17..||Goldin JG,Lynch DA,Strollo DC,et al. High resolution CT findings in scleroderma-related lung diseases: findings from Scleroderma Lung StudyChestYear: 200813435836710.1378/chest.07-244418641099|
|18..||Kim EA,Johkoh T,Lee KS,et al. Interstitial pneumonia in progressive systemic sclerosis: serial high-resolution CT findings with functional correlationJ Comput Assist TomogrYear: 20012575776310.1097/00004728-200109000-0001511584237|
|19..||Fujita J,Yoshinouchi T,Ohtsuki Y,et al. Non-specific interstitial pneumonia as pulmonary involvement of systemic sclerosisAnn Rheum DisYear: 20016028128310.1136/ard.60.3.28111171693|
|20..||Muller NL,Colby TV. Idiopathic interstitial pneumonias: high-resolution CT and histologic findingsRadiographicsYear: 199717101610229225401|
|21..||Latsi PI,Wells AU. Evaluation and management of alveolitis and interstitial lung disease in sclerodermaCurr Opin RheumatolYear: 20031574875510.1097/00002281-200311000-0001114569205|
|22..||Lynch DA. Nonspecific interstitial pneumonia: evolving conceptsRadiologyYear: 200122158358410.1148/radiol.221301151011719646|
|23..||Bouros D,Wells AU,Nicholson AG,et al. Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcomeAm J Respir Crit Care MedYear: 20021651581158610.1164/rccm.210601212070056|
|24..||Kim DS,Yoo B,Lee JS,et al. The major histopathologic pattern of pulmonary fibrosis in scleroderma is nonspecific interstitial pneumoniaSarcoidosis Vasc Diffuse Lung DisYear: 20021912112712108451|
|25..||Minai OA,Dweik RA,Arroliga AC. Manifestations of scleroderma pulmonary diseaseClin Chest MedYear: 19981971373110.1016/S0272-5231(05)70112-X9917962|
|26..||Hunninghake GW,Lynch DA,Galvin JR,et al. Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumoniaChestYear: 20031241215122310.1378/chest.124.4.121514555549|
|27..||Colby TV,Carrington CB. Thurlbeck WM,Churg AMInterstitial lung diseasePathology of the LungYear: 1995New YorkThieme Medical Publishers589737|
|28..||Piper WN,Helwig EB. Progressive systemic sclerosis: visceral manifestations in generalized sclerodermaAMA Arch DermYear: 19557253554613268058|
|29..||Fischer A,Swigris JJ,Groshong SD,et al. Clinically significant interstitial lung disease in limited scleroderma: histopathology, clinical features, and survivalChestYear: 200813460160510.1378/chest.08-005318403656|
|30..||Clements PJ,Roth MD,Elashoff R,et al. Scleroderma Lung Study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosisAnn Rheum DisYear: 2007661641164710.1136/ard.2007.06951817485423|
|31..||Kazerooni EA,Martinez FJ,Flint A,et al. Thin-section CT obtained at 10-mm increments versus limited three-level thin-section CT for idiopathic pulmonary fibrosis: correlation with pathologic scoringAJR Am J RoentgenolYear: 19971699779839308447|
|32..||Goh NS,Desai SR,Veeraraghavan S,et al. Interstitial lung disease in systemic sclerosis: a simple staging systemAm J Respir Crit Care MedYear: 20081771248125410.1164/rccm.200706-877OC18369202|
|33..||Kim HJ,Li G,Gjertson D,et al. Classification of parenchymal abnormality in scleroderma lung using a novel approach to denoise images collected via a multicenter studyAcad RadiolYear: 2008151004101610.1016/j.acra.2008.03.01118620121|
|34..||Wells AU,Rubens MB,Bois RM,Hansell DM. Serial CT in fibrosing alveolitis: prognostic significance of the initial patternAJR Am J RoentgenolYear: 1993161115911658249719|
|35..||Wells AU. High-resolution computed tomography and scleroderma lung diseaseRheumatology (Oxford)Year: 200847Suppl 5v59v6110.1093/rheumatology/ken27118784149|
|36..||Tashkin DP,Elashoff R,Clements PJ,et al. Cyclophosphamide versus placebo in scleroderma lung diseaseN Engl J MedYear: 20063542655266610.1056/NEJMoa05512016790698|
|37..||Strange C,Bolster MB,Roth MD,et al. Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung diseaseAm J Respir Crit Care MedYear: 2008177919810.1164/rccm.200705-655OC17901414|
|38..||Shah RM,Jimenez S,Wechsler R. Significance of ground-glass opacity on HRCT in long-term follow-up of patients with systemic sclerosisJ Thorac ImagingYear: 20072212012410.1097/01.rti.0000213572.16904.4017527113|
|39..||Giacomelli R,Valentini G,Salsano F,et al. Cyclophosphamide pulse regimen in the treatment of alveolitis in systemic sclerosisJ RheumatolYear: 20022973173611950014|
|40..||Griffiths B,Miles S,Moss H,et al. Systemic sclerosis and interstitial lung disease: a pilot study using pulse intravenous methylprednisolone and cyclophosphamide to assess the effect on high resolution computed tomography scan and lung functionJ RheumatolYear: 2002292371237812415594|
|41..||Pakas I,Ioannidis JPA,Malagari K,et al. Cyclophosphamide with low or high dose prednisolone for systemic sclerosis lung diseaseJ RheumatolYear: 20022929830411842824|
|42..||Davas EM,Peppas C,Maragou M,et al. Intravenous cyclophosphamide pulse therapy for the treatment of lung disease associated with sclerodermaClin RheumatolYear: 19991845546110.1007/s10067005013810638770|
|43..||Goldin J,Elashoff R,Kim HJ,et al. Treatment of scleroderma-interstitial lung disease with cyclophosphamide is associated with less progressive fibrosis on serial thoracic high-resolution CT scan than placeboChestYear: 20091361333134010.1378/chest.09-010819892673|
|44..||McLaughlin V. Pulmonary arterial hypertension: the most devastating vascular complication of systemic sclerosisRheumatology (Oxford)Year: 200948Suppl 3iii25iii3110.1093/rheumatology/kep10719487219|
|45..||Kahan A,Coghlan G,McLaughlin V. Cardiac complications of systemic sclerosisRheumatology (Oxford)Year: 200948Suppl 3iii45iii4810.1093/rheumatology/kep11019487224|
|46..||Vonk Noordegraaf A,Naeije R. Right ventricular function in scleroderma-related pulmonary hypertensionRheumatology (Oxford)Year: 200847Suppl 5v42v4310.1093/rheumatology/ken28418784141|
|47..||Lahcene M,Oumnia N,Matougui N,et al. Esophageal dysmotility is scleroderma: a prospective study of 183 casesGastroenterol Clin BiolYear: 20093346646919540687|
|48..||Tobin RW,Pope CE 2nd,Pellegrini CA,et al. Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosisAm J Respir Crit Care MedYear: 1998158180418089847271|
|49..||Marie I,Dominique S,Levesque H,et al. Esophageal involvement and pulmonary manifestations in systemic sclerosisArthritis RheumYear: 20014534635410.1002/1529-0131(200108)45:4<346::AID-ART347>3.0.CO;2-L11501722|
|50..||Bhalla M,Silver RM,Shepard JA,McLoud TC. Chest CT in patients with scleroderma: prevalence of asymptomatic esophageal dilatation and mediastinal lymphadenopathyAJR Am J RoentgenolYear: 19931612692728333359|
Keywords: Keywords Scleroderma, CT lung disease review.
Previous Document: Gout, hyperuricemia, and Parkinson's disease: a protective effect?
Next Document: Assessment of the relationship between stenosis severity and distribution of coronary artery stenose...