| Imaging inflammation in stroke using magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 20979930 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stroke is the third leading cause of death, after myocardial infarction and cancer, and the leading cause of permanent disability in Western countries. Although anti-inflammatory drugs have shown very promising results in preclinical rodent studies, they appeared to be ineffective against stroke in clinical trials. In this context, non-invasive detection of inflammatory cells after brain ischemia could be helpful (i) to select patients who may benefit from anti-inflammatory treatment, and/or (ii) to target an adequate individualized therapeutic time window. Magnetic resonance imaging (MRI) coupled with injection of iron oxide nanoparticles, a contrast agent taken up by macrophages ex vivo and in vivo, appears to be a promising tool for this purpose. This review focuses on the use of this technique to image inflammation in pre-clinical and clinical studies of stroke. Despite current limitations, MRI of inflammation may become an important tool for the investigation of novel ischemic stroke therapeutics targeting inflammation. |
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Authors:
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F Chauveau; T H Cho; Y Berthezène; N Nighoghossian; M Wiart |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of clinical pharmacology and therapeutics Volume: 48 ISSN: 0946-1965 ISO Abbreviation: Int J Clin Pharmacol Ther Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-28 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423309 Medline TA: Int J Clin Pharmacol Ther Country: Germany |
Other Details:
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Languages: eng Pagination: 718-28 Citation Subset: IM |
Affiliation:
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CNRS, UMR 5220, Inserm, U630, Insa de Lyon, Creatis, Bron, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / diagnosis, pathology Ferric Compounds / diagnostic use Humans Inflammation / diagnosis*, etiology Magnetic Resonance Imaging / methods* Metal Nanoparticles Patient Selection Rodentia Stroke / diagnosis*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Ferric Compounds; 1309-37-1/ferric oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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