| Imaging fibrillation/defibrillation in a dish. | |
| | |
MedLine Citation:
|
PMID: 17993331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Sheets of cultured cardiac cells constitute an emerging experimental model of cardiac tissue electrophysiology and arrhythmia. It has been used to study fundamental properties of reentrant (spiral) waves and electric field interactions with tissue structure and thus constitutes a valuable model for investigations of fibrillation and defibrillation. METHODS: Optical mapping can be used to visualize action potential propagation or calcium waves in confluent monolayers of neonatal rat ventricular cells. Spiral waves can be initiated by burst pacing and terminated by an electric field shock. RESULTS: Work from this laboratory and others is reviewed regarding the behavior of single and multiple spiral waves in this model system as they pertain to fibrillation (dynamic instabilities) and defibrillation (interaction of electric fields with reentrant waves). CONCLUSIONS: Subject to limitations, the cultured cell monolayer is a controlled experimental model that will be useful for further study of basic aspects of fibrillation and defibrillations. |
| | |
Authors:
|
Leslie Tung; Joshua Cysyk |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Journal of electrocardiology Volume: 40 ISSN: 1532-8430 ISO Abbreviation: J Electrocardiol Publication Date: 2007 Nov-Dec |
Date Detail:
|
Created Date: 2007-11-12 Completed Date: 2008-01-07 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: United States |
Other Details:
|
Languages: eng Pagination: S62-5 Citation Subset: IM |
Affiliation:
|
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA. ltung@jhu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Diagnostic Imaging / methods* Electric Countershock / methods* Heart Conduction System / pathology, physiopathology* Humans Image Interpretation, Computer-Assisted / methods* Myocytes, Cardiac / pathology*, physiology* Ventricular Fibrillation / diagnosis, physiopathology*, prevention & control |
| Grant Support | |
ID/Acronym/Agency:
|
EB006171/EB/NIBIB NIH HHS; HL66239/HL/NHLBI NIH HHS; R01 HL047678-14/HL/NHLBI NIH HHS; RR017073/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Imaging ventricular fibrillation.
Next Document: Acetylcholine-induced shortening of the epicardial action potential duration may increase repolariza...