| Imaging in arthritis: quantifying effects of therapeutic intervention using MRI and molecular imaging. | |
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MedLine Citation:
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PMID: 22252245 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Modern imaging techniques are becoming increasingly important in assessing the course of arthritis and in permitting measurement of response to treatment as part of the follow-up of patients. They include ultrasonography (US), MRI, PET/CT, and biofluorescence. In patients with rheumatoid arthritis, clinical evaluation is significantly less sensitive than either US or MRI in detecting synovitis. As a result, imaging is a useful alternative to achieving proper assessment of disease activity. The different areas in which the new imaging techniques could help practicing rheumatologists and internal physicians include the following: early and differential diagnosis of arthritis, evaluation of disease activity, prognosis, assessment of treatment efficacy, assessment of remission, and evaluation of subclinical disease. MRI is probably the best imaging method to study disease activity in RA, because it can study all the joints with similar efficacy, has been sufficiently standardised, and yields data on inflammation that can be quantified. Different methods, developed to score synovitis activity, are increasingly used in clinical trials. The main application of PET/CT in rheumatology is the diagnosis and follow-up of large vessel vasculitis. More recently, also RA disease activity has been evaluated, allowing a panoramic view of the patient. Molecular imaging studies molecular and cellular processes in intact living organisms in a non-invasive fashion. In fluorescence, dyes, that emit light upon excitation by a light source and are read by a camera, can be used to show inflamed areas where neoangiogenesis, vasodilatation, and increased vessel permeability are present. These dyes can be coupled with different compounds including antibodies and drugs. |
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Authors:
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M A Cimmino; F Barbieri; G Zampogna; D Camellino; F Paparo; M Parodi |
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Publication Detail:
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Type: Journal Article Date: 2012-01-05 |
Journal Detail:
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Title: Swiss medical weekly Volume: 141 ISSN: 1424-3997 ISO Abbreviation: Swiss Med Wkly Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100970884 Medline TA: Swiss Med Wkly Country: Switzerland |
Other Details:
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Languages: eng Pagination: w13326 Citation Subset: IM |
Affiliation:
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Clinica Reumatologica, Dipartimento di Medicina Interna e Specialità Mediche, Viale Benedetto XV, 6, 16132 Genova, IT. cimmino@unige.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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