Document Detail

Imaging features of copper deficiency myelopathy: a study of 25 cases.
MedLine Citation:
PMID:  16261334     Owner:  NLM     Status:  MEDLINE    
Acquired copper deficiency presents with a spastic gait and sensory ataxia. Spinal cord magnetic resonance imaging (MRI) in patients with copper deficiency myelopathy may show increased T2 signal, most commonly in the dorsal midline cervical and thoracic cord. These imaging findings may be reversible with normalization of serum copper. The clinical and imaging picture is very similar to the subacute combined degeneration seen in patients with vitamin B12 deficiency. Neuroradiologists should consider this possibility when a long segment of symmetric dorsal spinal cord T2-hyperintensity is identified.
Neeraj Kumar; J Eric Ahlskog; Christopher J Klein; John D Port
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Publication Detail:
Type:  Journal Article     Date:  2005-10-28
Journal Detail:
Title:  Neuroradiology     Volume:  48     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-08     Completed Date:  2006-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  78-83     Citation Subset:  IM    
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Copper / deficiency*
Gait Ataxia / etiology*
Magnetic Resonance Imaging / methods*
Middle Aged
Muscle Spasticity / etiology
Spinal Cord Diseases / diagnosis,  etiology,  pathology*
Reg. No./Substance:

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