| Imaging features of colorectal liver metastasis in FDG PET-CT: a retrospective correlative analysis between CT attenuation and FDG uptake. | |
| | |
MedLine Citation:
|
PMID: 22273638 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: Increasing scientific evidence supports the use of fluorodeoxyglucose positron emission tomography/ computed tomography (FDG-PET/CT) in the staging of colorectal carcinoma. A detailed and accurate characterization of tumor biology and imaging characteristics is therefore of paramount importance. The aim of our study was to determine whether CT attenuation, in Hounsfield units, was correlated with FDG uptake in colorectal liver metastasis. METHODS: The clinical and imaging data of patients from our institution with histologically proven colorectal carcinoma who were referred for PET/CT staging were reviewed. For the purpose of our study, we included only those patients who had undergone dual-time-point imaging. A total of 20 patients with 62 hepatic secondaries were identified. The perlesional CT attenuation (in Hounsfield units), FDG uptake (in standardized uptake values SUV60 and SUV120), and size (in cm) were determined. Correlation analysis using the Spearman rank correlation coefficient was carried out. RESULTS: A statistically significant positive relationship was observed between perlesional CT attenuation and SUV60 (r=0.433, P=0.0004). A similar significant positive relationship was shown between perlesional CT attenuation and SUV120 (r=0.414, P=0.0008). CONCLUSION: Our study suggested that, in colorectal liver metastasis, FDG uptake was positively correlated with CT attenuation. If a lesion appeared to be indeterminate because of apparently low FDG avidity, internal content must be taken into consideration to minimize misdiagnosis and false negatives. We proposed that such a relationship may be due to the mucinous contents of colorectal liver metastasis or degree of tumor necrosis. Further research, particularly on quantification of the extent of mucin production and tumor necrosis, may allow a more precise relationship to be drawn between CT attenuation and FDG uptake. |
| | |
Authors:
|
Andrea Wai San Au-Yeung; Wing Hang Luk; Adrian Xu Ning Lo |
Related Documents
:
|
15338668 - The secret of the phantom stone: a case report. 2443098 - Lack of amyloid in abdominal fat aspirates from patients undergoing long-term hemodialy... 22174518 - Crossed cerebellar diaschisis on f-18 fdg pet/ct. 21757148 - Facial palsy as unusual complication of spontaneous intraparotid hematoma. 6976688 - Problems with contrast-detail curves for ct performance evaluation. 17707938 - A study on adaptive imrt treatment planning using kv cone-beam ct. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-23 |
Journal Detail:
|
Title: Nuclear medicine communications Volume: - ISSN: 1473-5628 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Radiology, United Christian Hospital, Kwun Tong, Hong Kong. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Twistable and bendable actuator: a CNT/polymer sandwich structure driven by thermal gradient.
Next Document: Potential genotoxic effect of 186Re-HEDP on human lymphocyte cells: in-vitro evaluation with micron...