Document Detail

Imaging evaluation of acute ischemic stroke.
MedLine Citation:
PMID:  21164129     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Imaging is an important aspect of decisions regarding treatment for acute stroke. New imaging techniques using MRI and CT enable estimation of tissue viability. This information may be useful to select patients for acute stroke therapies.
SUMMARY OF REPORT: Several clinical trials identified patients with penumbra based on MRI or CT imaging. The results indicate patients with penumbra by imaging improve with reperfusion, but it is not yet clear that thrombolysis is beneficial when patients are selected on this basis. New quantitative techniques for assessing perfusion and diffusion may improve these results.
CONCLUSIONS: Identifying reversible patterns on MRI or CT perfusion imaging may ultimately yield better results than the mismatch concept that is currently under active investigation.
Lawrence R Wechsler
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-12-16
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  42     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-28     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S12-5     Citation Subset:  IM    
Department of Neurology, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
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MeSH Terms
Acute Disease
Brain Ischemia / radiography*,  therapy
Magnetic Resonance Imaging / methods*
Stroke / radiography*,  therapy
Tomography, X-Ray Computed / methods*

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